轻度认知障碍的听觉 P50 门控：病例对照研究

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2022-01-01 DOI:10.1177/15333175211068966

Weidong Song, Xiaohui Hu, Guohua Xie, Wentao Lai, Yang Wang, Donghui Wu

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引用次数: 0

摘要

目的听觉 P50 门控的变化可能是诊断轻度认知障碍（MCI）的神经生理学生物标志物。我们旨在确定 MCI 对听觉 P50 选通的影响。研究方法所有受试者填写结构化问卷并完成听觉 P50 门控测量。结果共招募了 20 名 MCI 患者和 17 名对照者。与对照组相比，MCI患者在Fz部位的P50门控下降幅度明显更高（1.21 ± .68 vs .66 ± .37，P = .00）。零点五是区分 MCI 和对照组 Fz 位置听觉 P50 选通 S2/S1 的最佳切点。MCI患者Pz部位的P50平均振幅明显高于对照组（2.62 ± 1.20 vs 1.70 ± .74，P = .01）。结论MCI患者抑制重复刺激的能力可能受损。

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The Auditory P50 Gating in Mild Cognitive Impairment: A Case-Control Study.

Objective: Auditory P50 gating changed might be a neurophysiological biomarker of the diagnosis of Mild Cognitive Impairment (MCI). We aimed to determine the impact of MCI in auditory P50 gating. Methods: All recruited participants completed structured questionnaires and finished auditory P50 gating measure. Results: A total of 20 MCI patients and 17 controls had been recruited. MCI patients had a significant higher reduction of P50 gating at Fz site, when compared to controls (1.21 ± .68 vs .66 ± .37, P = .00). Zero point five was the best cut off point to distinguish MCI and control of auditory P50 gating S2/S1 at Fz site. The P50 average amplitude at Pz site in MCI patients was significantly higher than controls (2.62 ± 1.20 vs 1.70 ± .74, P = .01). Conclusion: MCI patients might have impaired the ability of inhibiting the repeated stimulus.

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).