{"title":"胶质母细胞瘤:大脑的杂草。","authors":"Anna Roberts, Mark Roughley, Caroline Wilkinson","doi":"10.1080/17453054.2021.2010521","DOIUrl":null,"url":null,"abstract":"In the changing landscape of medicine, cancer comes as a priority. 11,000 people are diagnosed with a brain tumour each year in the United Kingdom (NHS, 2020); however, only 1% of funding is attributed (Scott, 2021). ‘Glioblastoma: The Weed of the Brain’ is a research project that aims to engage audiences on Glioblastoma Multiforme (GBM), currently recognised as the most aggressive brain tumour in medical literature (Duma, 2016). The tumour forms in the astrocyte cells that reside within the glial cells, found in the brain and spinal cord (Cancer research UK, n.d.). The tumour insidiously spreads through the white matter pathways within the brain (Duma, 2016) in a process known as angiogenesis; in which tumour cells invade healthy brain tissue and gain oxygen from blood vessel to increase its spread (Grisham, 2014). This growth pattern attests to the tumours’ complexity but also why no treatment has led to a successful prognosis. Current treatments have only sought to prolong the life expectancy from around 12 to 18 months (Methodist, 2019); through surgery, chemotherapy and radiation (Brem & Abdullah, 2017). These methods have proven harmful to brain cells and indicate a lack of acknowledgement for other methods, such as botany in medicine.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glioblastoma: The Weed of the Brain.\",\"authors\":\"Anna Roberts, Mark Roughley, Caroline Wilkinson\",\"doi\":\"10.1080/17453054.2021.2010521\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the changing landscape of medicine, cancer comes as a priority. 11,000 people are diagnosed with a brain tumour each year in the United Kingdom (NHS, 2020); however, only 1% of funding is attributed (Scott, 2021). ‘Glioblastoma: The Weed of the Brain’ is a research project that aims to engage audiences on Glioblastoma Multiforme (GBM), currently recognised as the most aggressive brain tumour in medical literature (Duma, 2016). The tumour forms in the astrocyte cells that reside within the glial cells, found in the brain and spinal cord (Cancer research UK, n.d.). The tumour insidiously spreads through the white matter pathways within the brain (Duma, 2016) in a process known as angiogenesis; in which tumour cells invade healthy brain tissue and gain oxygen from blood vessel to increase its spread (Grisham, 2014). This growth pattern attests to the tumours’ complexity but also why no treatment has led to a successful prognosis. Current treatments have only sought to prolong the life expectancy from around 12 to 18 months (Methodist, 2019); through surgery, chemotherapy and radiation (Brem & Abdullah, 2017). These methods have proven harmful to brain cells and indicate a lack of acknowledgement for other methods, such as botany in medicine.\",\"PeriodicalId\":1,\"journal\":{\"name\":\"Accounts of Chemical Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":16.4000,\"publicationDate\":\"2022-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Accounts of Chemical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/17453054.2021.2010521\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17453054.2021.2010521","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/11 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
In the changing landscape of medicine, cancer comes as a priority. 11,000 people are diagnosed with a brain tumour each year in the United Kingdom (NHS, 2020); however, only 1% of funding is attributed (Scott, 2021). ‘Glioblastoma: The Weed of the Brain’ is a research project that aims to engage audiences on Glioblastoma Multiforme (GBM), currently recognised as the most aggressive brain tumour in medical literature (Duma, 2016). The tumour forms in the astrocyte cells that reside within the glial cells, found in the brain and spinal cord (Cancer research UK, n.d.). The tumour insidiously spreads through the white matter pathways within the brain (Duma, 2016) in a process known as angiogenesis; in which tumour cells invade healthy brain tissue and gain oxygen from blood vessel to increase its spread (Grisham, 2014). This growth pattern attests to the tumours’ complexity but also why no treatment has led to a successful prognosis. Current treatments have only sought to prolong the life expectancy from around 12 to 18 months (Methodist, 2019); through surgery, chemotherapy and radiation (Brem & Abdullah, 2017). These methods have proven harmful to brain cells and indicate a lack of acknowledgement for other methods, such as botany in medicine.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.