{"title":"角闪孔矿物颗粒主要类型的尺寸特征及其对致癌风险评估的影响。","authors":"Andrey A Korchevskiy, Ann G Wylie","doi":"10.1080/08958378.2021.2024304","DOIUrl":null,"url":null,"abstract":"<p><p><b>Context:</b> Though some significant advances have been made in recent decades to evaluate the importance of size and morphology (habit) of elongate mineral particles (EMPs), further research is needed to better understand the role of each dimensional metric in determining the levels of cancer potency.<b>Objective:</b> To determine dimensional parameters most relevant for predicting cancer potency of durable elongate particles, specifically amphibole and durable silicate minerals generally.<b>Methods:</b> A database on dimensional and other relevant characteristics of elongate amphibole mineral particles was created, containing particle-by-particle information for 128 099 particles. Integral statistical characteristics on dimensionality of various amphibole types and morphological habits of EMPs were calculated, compared, and correlated with published mesothelioma and lung cancer potency factors.<b>Results:</b> The highest absolute Pearson correlation (<i>r</i> = 0.97, <i>r</i><sup>2</sup> = 0.94, <i>p</i> < 0.05) was achieved between mesothelioma potency (R<sub>M</sub>) and specific surface area. The highest correlation with adjusted lung cancer potency was found with particle aspect ratio (AR) (<i>r</i> = 0.80, <i>r</i><sup>2</sup> = 0.64, <i>p</i> < 0.05). Cluster analysis demonstrates that fractions of thin fibers (width less than 0.15 and 0.25 µm) also closely relate both to lung cancer and R<sub>M</sub>. Asbestiform and non-asbestiform populations of amphiboles significantly differ by dimensionality and carcinogenic potency.<b>Conclusions:</b> Dimensional parameters and morphological habits of EMPs are the main drivers for the observable difference in cancer potency among amphibole populations.</p>","PeriodicalId":13561,"journal":{"name":"Inhalation Toxicology","volume":"34 1-2","pages":"24-38"},"PeriodicalIF":2.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"13","resultStr":"{\"title\":\"Dimensional characteristics of the major types of amphibole mineral particles and the implications for carcinogenic risk assessment.\",\"authors\":\"Andrey A Korchevskiy, Ann G Wylie\",\"doi\":\"10.1080/08958378.2021.2024304\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b>Context:</b> Though some significant advances have been made in recent decades to evaluate the importance of size and morphology (habit) of elongate mineral particles (EMPs), further research is needed to better understand the role of each dimensional metric in determining the levels of cancer potency.<b>Objective:</b> To determine dimensional parameters most relevant for predicting cancer potency of durable elongate particles, specifically amphibole and durable silicate minerals generally.<b>Methods:</b> A database on dimensional and other relevant characteristics of elongate amphibole mineral particles was created, containing particle-by-particle information for 128 099 particles. Integral statistical characteristics on dimensionality of various amphibole types and morphological habits of EMPs were calculated, compared, and correlated with published mesothelioma and lung cancer potency factors.<b>Results:</b> The highest absolute Pearson correlation (<i>r</i> = 0.97, <i>r</i><sup>2</sup> = 0.94, <i>p</i> < 0.05) was achieved between mesothelioma potency (R<sub>M</sub>) and specific surface area. The highest correlation with adjusted lung cancer potency was found with particle aspect ratio (AR) (<i>r</i> = 0.80, <i>r</i><sup>2</sup> = 0.64, <i>p</i> < 0.05). Cluster analysis demonstrates that fractions of thin fibers (width less than 0.15 and 0.25 µm) also closely relate both to lung cancer and R<sub>M</sub>. Asbestiform and non-asbestiform populations of amphiboles significantly differ by dimensionality and carcinogenic potency.<b>Conclusions:</b> Dimensional parameters and morphological habits of EMPs are the main drivers for the observable difference in cancer potency among amphibole populations.</p>\",\"PeriodicalId\":13561,\"journal\":{\"name\":\"Inhalation Toxicology\",\"volume\":\"34 1-2\",\"pages\":\"24-38\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2022-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Inhalation Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/08958378.2021.2024304\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Inhalation Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/08958378.2021.2024304","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/10 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"TOXICOLOGY","Score":null,"Total":0}
引用次数: 13
摘要
背景:尽管近几十年来在评估细长矿物颗粒(EMPs)的大小和形态(习惯)的重要性方面取得了一些重大进展,但需要进一步的研究来更好地了解每个尺寸度量在确定癌症效力水平方面的作用。目的:确定预测耐久长颗粒(尤其是角闪孔和耐久硅酸盐矿物)癌变能力的最相关尺寸参数。方法:建立一个细长角闪孔矿物颗粒尺寸及其他相关特征数据库,包含128099个颗粒的颗粒信息。计算、比较各种角闪孔类型的维数和emp的形态习惯的整体统计特征,并将其与已发表的间皮瘤和肺癌潜能因子进行关联。结果:与比表面积的绝对Pearson相关性最高(r = 0.97, r2 = 0.94, p M)。颗粒纵横比(AR)与校正后肺癌效力相关性最高(r = 0.80, r2 = 0.64, p < 0.05)。含石棉和非含石棉的角闪石种群在维数和致癌性方面存在显著差异。结论:EMPs的尺寸参数和形态习惯是角闪石种群间癌症效力差异的主要驱动因素。
Dimensional characteristics of the major types of amphibole mineral particles and the implications for carcinogenic risk assessment.
Context: Though some significant advances have been made in recent decades to evaluate the importance of size and morphology (habit) of elongate mineral particles (EMPs), further research is needed to better understand the role of each dimensional metric in determining the levels of cancer potency.Objective: To determine dimensional parameters most relevant for predicting cancer potency of durable elongate particles, specifically amphibole and durable silicate minerals generally.Methods: A database on dimensional and other relevant characteristics of elongate amphibole mineral particles was created, containing particle-by-particle information for 128 099 particles. Integral statistical characteristics on dimensionality of various amphibole types and morphological habits of EMPs were calculated, compared, and correlated with published mesothelioma and lung cancer potency factors.Results: The highest absolute Pearson correlation (r = 0.97, r2 = 0.94, p < 0.05) was achieved between mesothelioma potency (RM) and specific surface area. The highest correlation with adjusted lung cancer potency was found with particle aspect ratio (AR) (r = 0.80, r2 = 0.64, p < 0.05). Cluster analysis demonstrates that fractions of thin fibers (width less than 0.15 and 0.25 µm) also closely relate both to lung cancer and RM. Asbestiform and non-asbestiform populations of amphiboles significantly differ by dimensionality and carcinogenic potency.Conclusions: Dimensional parameters and morphological habits of EMPs are the main drivers for the observable difference in cancer potency among amphibole populations.
期刊介绍:
Inhalation Toxicology is a peer-reviewed publication providing a key forum for the latest accomplishments and advancements in concepts, approaches, and procedures presently being used to evaluate the health risk associated with airborne chemicals.
The journal publishes original research, reviews, symposia, and workshop topics involving the respiratory system’s functions in health and disease, the pathogenesis and mechanism of injury, the extrapolation of animal data to humans, the effects of inhaled substances on extra-pulmonary systems, as well as reliable and innovative models for predicting human disease.