锌在骨间充质干细胞分化中的作用。

IF 1.2 4区医学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Cellular reprogramming Pub Date : 2022-04-01 Epub Date: 2022-02-16 DOI:10.1089/cell.2021.0137

Huiyun Li, Muzhe Li, Xun Ran, Juncheng Cui, Fu Wei, Guoliang Yi, Wei Chen, Xuling Luo, Zhiwei Chen

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引用次数: 5

摘要

锌是人体骨骼生长和骨骼平衡所必需的微量元素。骨间充质干细胞(BMSCs)是存在于骨髓基质中的多能祖细胞，具有沿多种谱系途径分化的能力。锌在骨髓间充质干细胞中起着至关重要的作用，它可以刺激骨髓间充质干细胞分化成成骨细胞、软骨细胞或脂肪细胞，并调节破骨细胞的形成和活性。在不同细胞表型的分化过程中，相关基因的表达也发生了变化。鉴于锌在骨髓间充质干细胞分化中的重要作用，利用锌作为骨重塑的治疗手段将是一种很有前途的方法。本文综述了锌离子在骨髓间充质干细胞向不同表型分化中的作用，并概述了其分子机制的研究现状。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of Zinc in Bone Mesenchymal Stem Cell Differentiation.

Zinc is an essential trace element for bone growth and bone homeostasis in the human body. Bone mesenchymal stem cells (BMSCs) are multipotent progenitors existing in the bone marrow stroma with the capability of differentiating along multiple lineage pathways. Zinc plays a paramount role in BMSCs, which can be spurred differentiating into osteoblasts, chondrocytes, or adipocytes, and modulates the formation and activity of osteoclasts. The expression of related genes also changed during the differentiation of various cell phenotypes. Based on the important role of zinc in BMSC differentiation, using zinc as a therapeutic approach for bone remodeling will be a promising method. This review explores the role of zinc ion in the differentiation of BMSCs into various cell phenotypes and outlines the existing research on their molecular mechanism.

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来源期刊

Cellular reprogramming CELL & TISSUE ENGINEERING-BIOTECHNOLOGY & APPLIED MICROBIOLOGY

CiteScore

2.50

自引率

6.20%

发文量

审稿时长

3 months

期刊介绍： Cellular Reprogramming is the premier journal dedicated to providing new insights on the etiology, development, and potential treatment of various diseases through reprogramming cellular mechanisms. The Journal delivers information on cutting-edge techniques and the latest high-quality research and discoveries that are transforming biomedical research. Cellular Reprogramming coverage includes: Somatic cell nuclear transfer and reprogramming in early embryos Embryonic stem cells Nuclear transfer stem cells (stem cells derived from nuclear transfer embryos) Generation of induced pluripotent stem (iPS) cells and/or potential for cell-based therapies Epigenetics Adult stem cells and pluripotency.