远端深静脉血栓形成与无症状动脉粥样硬化的潜在关联。

Angelo Adamo, Luca Spiezia, Valle Fabio Dalla, Giampiero Avruscio, Paolo Simioni
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引用次数: 1

摘要

背景先前有几项研究报道了特发性近端深静脉血栓(DVT)与动脉粥样硬化之间的关联,但自发性远端深静脉血栓是否与无症状动脉粥样硬化相关尚不清楚。方法对116例自发性DVT患者行颈动脉超声检查,检测斑块、评价血管内膜-中膜厚度(IMT)和踝肱指数(ABI)。57例(男/女19/38例,年龄54-78岁)远端DVT, 59例(男/女24/35例,年龄51-73岁)近端DVT。选取57名(男/女21/36名,年龄64-70岁)匹配的受试者作为对照组。结果远端或近端DVT患者颈动脉斑块与对照组比较无显著差异(p > 0.05)。与对照组(0.88±0.15 mm)相比,远端DVT(1.00±0.20 mm)和近端DVT(0.98±0.16 mm)患者颈动脉IMT (mean±SD)显著增加(p < 0.05)。结论自发性远端DVT与无症状动脉粥样硬化之间可能存在关联,证实了特发性近端DVT与无症状动脉粥样硬化之间的已知关联。需要更大规模的研究来证实我们的结果并评估其临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Potential Association between Distal Deep Vein Thrombosis and Asymptomatic Atherosclerosis.

Potential Association between Distal Deep Vein Thrombosis and Asymptomatic Atherosclerosis.

Potential Association between Distal Deep Vein Thrombosis and Asymptomatic Atherosclerosis.

Background  Several studies have previously reported an association between idiopathic proximal deep vein thrombosis (DVT) and atherosclerosis, but whether spontaneous distal DVT is associated with asymptomatic atherosclerosis is still unknown. Methods  Ultrasonography of the carotid arteries was done for plaque detection and intima-media thickness (IMT) evaluation, and the ankle-brachial index (ABI) in 116 patients with spontaneous DVT and without symptomatic atherosclerosis. Fifty-seven patients (M/F 19/38, age range 54-78 years) had distal DVT and 59 (M/F 24/35, age range 51-73 years) had proximal DVT. A group of 57 (M/F 21/36, age range 64-70 years) matched subjects acted as controls. Results  No significant difference was found in carotid plaques between patients with distal or proximal DVT versus controls ( p > 0.05 in all comparisons). Carotid IMT (mean ± SD) was significantly increased in patients with distal (1.00 ± 0.20 mm) and proximal (0.98 ± 0.16 mm) DVT versus controls (0.88 ± 0.15 mm, p <0.01 in both comparisons). An ABI £ 0.9 was found in 3/57 (5.3%) and 5/59 (8.5%) patients with distal and proximal DVT, respectively versus no controls with abnormal ABI. Conclusion  Our results revealed that there may be an association between spontaneous distal DVT and asymptomatic atherosclerosis, and confirmed the known association between idiopathic proximal DVT and asymptomatic atherosclerosis. Larger studies are needed to confirm our results and to evaluate their clinical implications.

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