{"title":"印度脑膜炎球菌疾病负担:系统回顾和荟萃分析。","authors":"Canna Jagdish Ghia, Gautam Sudhakar Rambhad","doi":"10.1177/11786361211053344","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To perform systematic review and meta-analysis of meningococcal disease burden in India.</p><p><strong>Methods: </strong>We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of <i>Meningococcal meningitis</i> and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively.</p><p><strong>Results: </strong>The prevalence of <i>Meningococcal meningitis</i> in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; <i>N. meningitis</i> caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance.</p><p><strong>Conclusion: </strong>The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.</p>","PeriodicalId":74187,"journal":{"name":"Microbiology insights","volume":"14 ","pages":"11786361211053344"},"PeriodicalIF":0.0000,"publicationDate":"2021-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/e7/10.1177_11786361211053344.PMC8637695.pdf","citationCount":"1","resultStr":"{\"title\":\"Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.\",\"authors\":\"Canna Jagdish Ghia, Gautam Sudhakar Rambhad\",\"doi\":\"10.1177/11786361211053344\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To perform systematic review and meta-analysis of meningococcal disease burden in India.</p><p><strong>Methods: </strong>We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of <i>Meningococcal meningitis</i> and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively.</p><p><strong>Results: </strong>The prevalence of <i>Meningococcal meningitis</i> in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; <i>N. meningitis</i> caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance.</p><p><strong>Conclusion: </strong>The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.</p>\",\"PeriodicalId\":74187,\"journal\":{\"name\":\"Microbiology insights\",\"volume\":\"14 \",\"pages\":\"11786361211053344\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-11-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/34/e7/10.1177_11786361211053344.PMC8637695.pdf\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Microbiology insights\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/11786361211053344\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbiology insights","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11786361211053344","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.
Objective: To perform systematic review and meta-analysis of meningococcal disease burden in India.
Methods: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar. Prevalence (proportion) of Meningococcal meningitis and Case-fatality ratio (CFR) were pooled using random effects model. Other outcomes were pooled qualitatively.
Results: The prevalence of Meningococcal meningitis in epidemic and endemic conditions was 12.1% (95% CI: 5.2-21.4) and 0.76% (95% CI: 0.3-1.4), respectively, with a CFR of 12.8% (95% CI: 6.8-20.4) in epidemic settings; N. meningitis caused 3.2% (95% CI: 1.6-5.3) of Acute Bacterial Meningitis (ABM) cases in endemic settings. The disease appeared in infants, adolescents, and adults with Serogroup A prevalence. Treatment and prophylaxis were limited to antibiotics despite increased resistance.
Conclusion: The study reveals epidemic and endemic presence of the disease in India with high fatality and serogroup A prevalence. Further monitoring and immunization are required to prevent outbreaks.
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