非酒精性脂肪肝在切尔诺贝利事故后早期的亚临床炎症

O V Nosach, E O Sarkissova, S M Alyokhina, O Ya Pleskach, O M Litvinets, L M Ovsyannikova, A A Chumak
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引用次数: 0

摘要

目的:探讨切尔诺贝利事故因素对非酒精性脂肪性肝病(NAFLD)患者术后远期炎症反应及氧化应激参数的影响。材料和方法:对82例因切尔诺贝利事故而暴露于电离辐射并伴有心血管病变的NAFLD患者进行了检查。测定血液学指标和高敏感c反应蛋白(hsCRP)水平,评价脂质和蛋白质氧化修饰产物的含量。结果:在大多数NAFLD患者中观察到脂质和蛋白质氧化修饰过程的激活。根据hsCRP水平,58%的NAFLD患者存在亚临床炎症和发展为复杂心血管病理的风险。中性粒细胞/淋巴细胞比率与hsCRP呈正相关,可作为选择心血管并发症风险增加的NAFLD患者的常规临床指标。结论:HsCRP、脂质和蛋白氧化修饰产物、ESR和白质图可用于评估受切尔诺贝利事故影响的NAFLD合并心血管疾病患者的全身炎症程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SUBCLINICAL INFLAMMATION IN NON/ALCOHOLIC FATTY LIVER DISEASE AT THE REMOTE PERIOD AFTER THE CHORNOBYL ACCIDENT.

Objective: to evaluate the parameters of inflammatory reaction and oxidative stress in patients with non-alcoholicfatty liver disease (NAFLD) in the remote period after the influence of the Chornobyl accident factors.

Materials and methods: Eighty two patients with NAFLD who had been exposed to ionizing radiation as a result ofthe Chornobyl accident and have concomitant cardiovascular pathology were examined. Hematological parametersand the level of highly sensitive C-reactive protein (hsCRP) were determined, and the content of products of oxida-tive modification of lipids and proteins was evaluated.

Results: Activation of the processes of oxidative modification of lipids and proteins was observed in most patientswith NAFLD. According to the level of hsCRP, the presence of subclinical inflammation and the risk of developingcomplicated cardiovascular pathology was found in 58 % of patients with NAFLD. The neutrophil / lymphocyte ratiocorrelates positively with hsCRP and can be used as an available routine clinical marker for selection among patientswith NAFLD persons with increased risk of cardiovascular complications.

Conclusions: HsCRP, oxidative modification products of lipids and proteins, ESR, and leukograms should be used toassess the degree of systemic inflammation in people affected by the Chornobyl accident, suffering NAFLD with con-comitant cardiovascular disease.

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Problemy radiatsiinoi medytsyny ta radiobiolohii
Problemy radiatsiinoi medytsyny ta radiobiolohii Medicine-Radiology, Nuclear Medicine and Imaging
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