吸烟与精神分裂症:病因学、临床、药理学和治疗意义。

IF 3.6 Q1 PSYCHIATRY
Schizophrenia Research and Treatment Pub Date : 2021-12-13 eCollection Date: 2021-01-01 DOI:10.1155/2021/7698030
Jack Baichao Ding, Kevin Hu
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引用次数: 11

摘要

最近的数据表明,精神分裂症患者的吸烟率仍然很高。虽然有报告表明吸烟会增加患精神分裂症的风险,但吸烟在这种关系中的潜在致病作用还需要进一步调查。与不吸烟的精神分裂症患者相比,吸烟的精神分裂症患者更有可能出现更强烈的阳性症状和更低的认知功能,但锥体外系副作用的强度更低。与不吸烟者相比,他们也更有可能表现出攻击性行为,这可能表明他们的基线攻击性水平更高。与定期烟草支出相关的巨额费用可能减损对关键领域的投资。大规模试验表明,药物治疗戒烟是有效的,与安慰剂相比,不会加重神经精神症状的风险。精神分裂症患者中电子烟的使用率很高,并且有新出现的证据支持其有效性。未来的改进包括评估精神分裂症患者使用电子烟的效用、有效性和安全性的大规模试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cigarette Smoking and Schizophrenia: Etiology, Clinical, Pharmacological, and Treatment Implications.

Cigarette Smoking and Schizophrenia: Etiology, Clinical, Pharmacological, and Treatment Implications.

Recent data suggests that the prevalence of smoking in schizophrenia remains high. While reports suggest that smoking increases the risk of developing schizophrenia, the potential causative role of smoking in this relationship needs further investigation. Smokers with schizophrenia are more likely to have more intense positive symptoms and lower cognitive function, but diminished intensity of extrapyramidal side effects than nonsmoking patients with schizophrenia. They were also more likely to exhibit aggressive behaviour compared to nonsmokers, which could suggest higher levels of baseline aggression. The significant cost associated with regular tobacco expenditure can detract from investment in key domains. Large-scale trials have shown that pharmacotherapy for smoking cessation is effective and does not worsen the risk of developing neuropsychiatric symptoms compared to placebo. Electronic cigarette use among schizophrenia patients is high, and there is emerging evidence supportive of its efficacy. Future improvements include large-scale trials assessing the utility, efficacy, and safety of electronic cigarettes in schizophrenia patients.

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来源期刊
CiteScore
4.60
自引率
0.00%
发文量
2
审稿时长
14 weeks
期刊介绍: Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.
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