Milton Ramírez-Piña, Santiago Monleón, Concepción Vinader-Caerols
{"title":"女性和男性青少年的下丘脑-垂体-肾上腺轴因暴饮模式而失调,而不是因急性酒精摄入而失调。","authors":"Milton Ramírez-Piña, Santiago Monleón, Concepción Vinader-Caerols","doi":"10.20882/adicciones.1665","DOIUrl":null,"url":null,"abstract":"<p><p>Excessive alcohol consumption is a worldwide public health problem, being adolescents and young adults the population most affected by this problem. The aim of this study was to clarify the effects of having a history of binge drinking (BD) and/or acute alcohol consumption on the stress response in female and male adolescents. Participants were 235 adolescents (143 females and 92 males). Cortisol, systolic and diastolic blood pressure (SBP and DBP), heart rate (HR) and perceived stress (PS) were evaluated in adolescents with different and similar blood alcohol concentrations (BAC). In Experiment 1, the effects of alcohol were studied separately in females and males because of differences in BAC. In Experiment 2, a direct comparison between sexes was carried out in a counterbalanced selection of participants with similar BAC. In Experiment 1, females receiving alcohol showed an increase in cortisol and HR, and binge drinkers displayed higher HR than refrainers. Male refrainers receiving alcohol showed higher HR, and binge drinkers showed higher cortisol and SBP than refrainers. In Experiment 2, similar results were observed and sex differences were evident, with males showing higher cortisol and SBP, and lower PS than females. In conclusion, the normal response of the adolescent HPA axis to alcohol consumption is an increase in cortisol levels in females, as well as HR in both sexes. In addition, a history of BD is associated with HPA axis dysregulation, which is manifested by higher values of cortisol (independently of sex), SBP in male and HR in female healthy adolescents.</p>","PeriodicalId":55560,"journal":{"name":"Adicciones","volume":"0 0","pages":"421-432"},"PeriodicalIF":2.2000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hypothalamic-pituitary-adrenal axis dysregulation initiated by a binge drinking pattern, but not by acute alcohol intake, in female and male adolescents.\",\"authors\":\"Milton Ramírez-Piña, Santiago Monleón, Concepción Vinader-Caerols\",\"doi\":\"10.20882/adicciones.1665\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Excessive alcohol consumption is a worldwide public health problem, being adolescents and young adults the population most affected by this problem. The aim of this study was to clarify the effects of having a history of binge drinking (BD) and/or acute alcohol consumption on the stress response in female and male adolescents. Participants were 235 adolescents (143 females and 92 males). Cortisol, systolic and diastolic blood pressure (SBP and DBP), heart rate (HR) and perceived stress (PS) were evaluated in adolescents with different and similar blood alcohol concentrations (BAC). In Experiment 1, the effects of alcohol were studied separately in females and males because of differences in BAC. In Experiment 2, a direct comparison between sexes was carried out in a counterbalanced selection of participants with similar BAC. In Experiment 1, females receiving alcohol showed an increase in cortisol and HR, and binge drinkers displayed higher HR than refrainers. Male refrainers receiving alcohol showed higher HR, and binge drinkers showed higher cortisol and SBP than refrainers. In Experiment 2, similar results were observed and sex differences were evident, with males showing higher cortisol and SBP, and lower PS than females. In conclusion, the normal response of the adolescent HPA axis to alcohol consumption is an increase in cortisol levels in females, as well as HR in both sexes. In addition, a history of BD is associated with HPA axis dysregulation, which is manifested by higher values of cortisol (independently of sex), SBP in male and HR in female healthy adolescents.</p>\",\"PeriodicalId\":55560,\"journal\":{\"name\":\"Adicciones\",\"volume\":\"0 0\",\"pages\":\"421-432\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Adicciones\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.20882/adicciones.1665\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Adicciones","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.20882/adicciones.1665","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
Hypothalamic-pituitary-adrenal axis dysregulation initiated by a binge drinking pattern, but not by acute alcohol intake, in female and male adolescents.
Excessive alcohol consumption is a worldwide public health problem, being adolescents and young adults the population most affected by this problem. The aim of this study was to clarify the effects of having a history of binge drinking (BD) and/or acute alcohol consumption on the stress response in female and male adolescents. Participants were 235 adolescents (143 females and 92 males). Cortisol, systolic and diastolic blood pressure (SBP and DBP), heart rate (HR) and perceived stress (PS) were evaluated in adolescents with different and similar blood alcohol concentrations (BAC). In Experiment 1, the effects of alcohol were studied separately in females and males because of differences in BAC. In Experiment 2, a direct comparison between sexes was carried out in a counterbalanced selection of participants with similar BAC. In Experiment 1, females receiving alcohol showed an increase in cortisol and HR, and binge drinkers displayed higher HR than refrainers. Male refrainers receiving alcohol showed higher HR, and binge drinkers showed higher cortisol and SBP than refrainers. In Experiment 2, similar results were observed and sex differences were evident, with males showing higher cortisol and SBP, and lower PS than females. In conclusion, the normal response of the adolescent HPA axis to alcohol consumption is an increase in cortisol levels in females, as well as HR in both sexes. In addition, a history of BD is associated with HPA axis dysregulation, which is manifested by higher values of cortisol (independently of sex), SBP in male and HR in female healthy adolescents.
期刊介绍:
Adicciones publica artículos originales sobre el tratamiento, la prevención, estudios básicos y descriptivos en el campo de las adicciones, como son las drogas ilegales, el alcohol, el tabaco o cualquier otra adicción, procedentes de distintas disciplinas (medicina, psicología, investigación básica, investigación social, etc.). Todos los artículos son seleccionados después de pasar un proceso de revisión anónimo hecho por expertos en ese tema.