囊性纤维化患者糖耐量受损和血糖不确定

IF 4.2 Q1 ENDOCRINOLOGY & METABOLISM
Nader Kasim , Swapnil Khare , Zahre Sandouk , Christine Chan
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引用次数: 7

摘要

口服糖耐量试验(OGTT)是筛查和诊断囊性纤维化相关性糖尿病(CFRD)的主要方法。目前定义的诊断阈值是基于2型糖尿病的微血管并发症。异常糖耐量(AGT)是指OGTT葡萄糖升高超出正常范围,包括糖耐量受损和不确定。目前的指南将糖耐量受损(IGT)定义为2小时葡萄糖水平为140-199 mg/dL (7.8-11 mmol/L),不确定糖耐量(INDET)定义为正常空腹和2小时葡萄糖水平下任何ogtt中期葡萄糖≥200 mg/dL (11.1 mmol/L)。越来越多的证据表明,AGT也与以cf为中心的结局相关,包括肺功能减退、住院和体重减轻。在这里,我们的目的是回顾糖耐量测试的历史出现,回顾与CFRD风险分层的相关性,讨论早期识别AGT的替代临界值,并强调需要进行更大规模的未来研究,以了解IGT和INDET对CF健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impaired glucose tolerance and indeterminate glycemia in cystic fibrosis

Oral glucose tolerance testing (OGTT) is the primary method to screen for and diagnose cystic fibrosis-related diabetes (CFRD). Diagnostic thresholds as currently defined are based on microvascular complications seen in type 2 diabetes. Abnormal glucose tolerance (AGT) refers to OGTT glucose elevations outside the normal range and encompasses both impaired and indeterminate glucose tolerance. Current guidelines define impaired glucose tolerance (IGT) as a 2-hour glucose of 140–199 mg/dL (7.8–11 mmol/L) and indeterminate glucose tolerance (INDET) as any mid-OGTT glucose ≥ 200 mg/dL (11.1 mmol/L) with a normal fasting and 2 h glucose. There is growing evidence that AGT also has associations with CF-centered outcomes including pulmonary decline, hospitalizations, and weight loss. Here we aim to review the historical emergence of glucose tolerance testing, review relevance to risk stratification for CFRD, discuss alternate cutoffs for identifying AGT earlier, and highlight the need for larger, future studies to inform our understanding of the implications of IGT and INDET on CF health.

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来源期刊
CiteScore
6.10
自引率
0.00%
发文量
24
审稿时长
16 weeks
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