前列腺特异性膜抗原在颈动脉体副神经节瘤中的意义。

IF 0.7 Q4 OTORHINOLARYNGOLOGY
Turkish Archives of Otorhinolaryngology Pub Date : 2021-09-01 Epub Date: 2021-10-15 DOI:10.4274/tao.2021.2021-3-17
Hasan Yasan, Yusuf Çağdaş Kumbul, İbrahim Metin Çiriş, Mehmet Emre Sivrice, Erdoğan Okur
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引用次数: 0

摘要

目的:前列腺特异性膜抗原(PSMA)是一种在前列腺癌中表达的跨膜蛋白。然而,它也在一些非前列腺实体瘤的新生血管中表达。颈动脉体副神经节瘤(CBPs)是高度血管性肿瘤。在这项研究中,我们旨在探讨PSMA表达在CBPs中的可能作用。文献中没有研究报告调查了PSMA和CBPs之间的关系。方法:本研究回顾性分析基于人口学、临床、放射学、手术和免疫组织化学结果诊断为CBP的病例。从患者档案中检索Ki-67、S100、synaptophysin、chromogranin的免疫组化检查结果。免疫组化法对CBPs标本石蜡块进行psma抗体染色,进行组织病理学检查。结果:手术治疗CBP患者12例(男4例,女8例)。12个标本中有10个适合染色和组织病理学检查。肿瘤包膜和/或血管浸润见于复杂病例。除1例外,其余标本均可见瘤内血管PSMA表达。在所有病例中均未检测到瘤外血管PSMA表达。10例中有6例可见肿瘤细胞PSMA染色。结论:PSMA在几乎所有CBPs中均有较高的肿瘤内血管表达,但由于样本数量少,我们无法评估其统计学意义。这些数据可能为未来的CBPs诊断或治疗方法研究提供指导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Importance of Prostate-Specific Membrane Antigen Expression in Carotid Body Paragangliomas.

The Importance of Prostate-Specific Membrane Antigen Expression in Carotid Body Paragangliomas.

The Importance of Prostate-Specific Membrane Antigen Expression in Carotid Body Paragangliomas.

The Importance of Prostate-Specific Membrane Antigen Expression in Carotid Body Paragangliomas.

Objective: Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in prostate cancer. It is, however, also expressed in the neovasculature of some non-prostatic solid tumors. Carotid body paragangliomas (CBPs) are highly vascular neoplasms. In this study, we aimed to investigate the possible role of PSMA expression in CBPs. There are no studies in the literature that report to have investigated the relationship between PSMA and CBPs.

Methods: This study is a retrospective analysis of cases diagnosed with CBP based on their demographic, clinical, radiological, surgical and immunohistochemical findings. Immunohistochemical examination results of Ki-67, S100, synaptophysin, chromogranin were retrieved from patient files. Then, the paraffin blocks of CBPs specimens, stained by PSMA-antibody by immunohistochemical methods were examined histopathologically.

Results: The number of patients operated on for CBP was 12 (four men and eight women). Ten out of 12 specimens were suitable for staining and histopathological examination. Capsular and/or vascular invasions of tumors were seen in complicated cases. Intratumoral vascular PSMA expression was seen in all specimens except one. Extratumoral vascular PSMA expression was not detected in any of the cases. Tumoral cell PSMA staining was seen in six of ten cases.

Conclusion: We found higher intratumoral vascular expressions of PSMA nearly in all CBPs, but we could not assess the statistical significance because of the small number of specimens. These data might be a guide for future studies that are planned for either diagnostic or therapeutic approaches to CBPs.

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