人乳低聚糖谱和2岁以下儿童特应性皮炎:Ulm SPATZ健康研究。

Linda P Siziba, Marko Mank, Bernd Stahl, Deborah Kurz, John Gonsalves, Bernadet Blijenberg, Dietrich Rothenbacher, Jon Genuneit
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引用次数: 4

摘要

背景:人乳寡糖(HMOs)具有多种生物学功能。然而,很少有研究调查了HMOs对过敏发展的影响,甚至更少研究它们与儿童早期特应性皮炎(AD)的具体关系。目的:本研究调查了在两个哺乳时间点测量的个体HMO浓度是否与两岁以下儿童AD的报告诊断相关。方法:在哺乳6周(n = 534)和6个月(n = 356)采集的人乳样本中测量HMOs的结果数据。从父母和儿科医生在1岁和2岁时确定的hmo与AD的关系,在粗糙和调整的逻辑回归模型中进行评估。结果:在常规水平上,很少有关联具有统计学意义(p .0031,这是经多重检验校正后具有统计学意义的阈值)。结论:我们的研究结果表明,在本研究中,在哺乳6周和6个月时摄入不同水平(甚至缺乏)的个体HMOs与儿童早期AD的发展没有显著相关性。考虑到我们研究的探索性和有限的样本量,这些结果应该谨慎解释。我们在常规水平上显示出合理关联的特定hmo可能需要进一步的研究和调查。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Human milk oligosaccharide profiles and child atopic dermatitis up to 2 years of age: The Ulm SPATZ Health Study.

Background: Human milk oligosaccharides (HMOs) have several biological functions. Yet, very few studies have investigated the effect of HMOs on the development of allergies and even fewer on their specific associations with atopic dermatitis (AD) during early childhood.

Objective: This study investigated whether individual HMO concentrations, measured at two time points of lactation, were associated with reported diagnosis of AD in children up to two years of age.

Method: Outcome data were available for HMOs measured in human milk samples collected at 6 weeks (n = 534) and 6 months (n = 356) of lactation. Associations of HMOs with AD, ascertained from parents and pediatricians at ages one and two years, were assessed in crude and adjusted logistic regression models.

Results: Few associations were statistically significant at the conventional level (p < .05), for example, 6-week Lacto-N-neotetraose with 2-year AD [OR 95%CI: 0.82 (0.66, 1.00)] and 6-month 3'-sialyllactose among non-secretor mothers with 1-year AD [2.59 (1.53, 6.81)]. Importantly, accounting for multiple testing, these and all further associations were not statistically significant (all p > .0031, which is the threshold for statistical significance after correction for multiple testing).

Conclusion: Our findings suggest that the intake of different levels (or even absence) of the individual HMOs measured at 6 weeks and 6 months of lactation, in the current study, is not significantly associated with the development of AD in early childhood. Given the exploratory nature of our study and the limited sample size, these results should be interpreted with caution. The specific HMOs for which we show plausible associations at conventional level may warrant further research and investigation.

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