一项随机、裂面对照试验,研究微针分数射频和分数掺铒玻璃1565 nm激光治疗下眼睑松弛的安全性和效果。

IF 1.2 4区 医学 Q3 DERMATOLOGY
Journal of Cosmetic and Laser Therapy Pub Date : 2021-08-01 Epub Date: 2021-11-23 DOI:10.1080/14764172.2021.2001532
Wenjie Dou, Qing Yang, Yue Yin, Xing Fan, Lihong Qiu, Zhe Yang, Zhe Jian, Wenting Song, Xianjie Ma
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引用次数: 2

摘要

非烧蚀分数掺铒玻璃1565 nm激光(NAFL)和微针分数射频(MFR)程序是有效的治疗,使眶周皮肤再生。比较MFR和NAFL治疗中国人群下眼睑松弛症的临床疗效和不良反应。15名中国患者每月随机接受3次分脸治疗。在基线以及第三次治疗后1个月和3个月进行客观和主观评估。使用antea - 3d和CineScan系统对结果进行评估。由两名整形外科医生进行盲法研究者评估,在六个解剖分类中使用0到4分。患者还报告了基于4分的满意度。大多数患者报告两种治疗的满意率均超过47%。眼眶脂肪脱垂、空心撕裂沟、皮肤松弛对各类别变量的累积贡献评分随时间而下降。使用Antera 3D, MFR组和NAFL组的高程体积(mm3)分别从0.6±0.4降至0.4±0.3和0.6±0.3降至0.3±0.3,高程面积(mm2)分别从17.0±8.4降至13.0±7.1和17.0±7.8降至10.0±5.6,最大峰高(mm)分别从0.10±0.04降至0.06±0.04和0.10±0.03降至0.06±0.02。使用CineScan, MFR组和NAFL组中眶脂肪深度(mm)分别从10.2±2.2减少到8.0±0.7和9.8±1.1减少到8.0±0.9,眶脂肪长度分别从9.2±1.2减少到7.7±0.7和9.7±1.4减少到7.8±0.6。MFR和NAFL治疗BLE疗效显著,尤其对伴有皮肤弹性、撕裂槽畸形和眶脂肪脱垂的BLE患者疗效显著。试验注册号:NCT04237324。试验注册:clinicaltrials .gov.证据等级:I级,治疗性研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A randomized, split-face controlled trial on the safety and effects of microneedle fractional radiofrequency and fractional erbium-doped glass 1,565-nm laser therapies for baggy lower eyelids.

The non-ablative fractional erbium-doped glass 1,565-nm laser (NAFL) and the microneedle fractional radiofrequency (MFR) procedures are effective treatments that enable periorbital skin rejuvenation. To compare the clinical effectiveness and side effects of MFR and the NAFL for baggy lower eyelids (BLEs) in the Chinese population. Fifteen Chinese subjects with BLEs received three split-face treatments on a monthly basis randomly. Objective and subjective assessments were performed at baseline, as well as 1 month and 3 months after the third treatment. The results were evaluated using Antera-3D and CineScan systems. Blinded investigator assessments were performed by two plastic surgeons using a 0 to 4 score in six anatomic categories of BLEs. The patients also reported their level of satisfaction based on a four-point score. Most of the patients reported a greater than 47% satisfaction rate with both treatments. The cumulative contribution scores of prolapse of orbital fat, hollow tear trough, and skin laxity for each category variable declined with time. Using Antera 3D, the volume of elevation (mm3) decreased from 0.6 ± 0.4 to 0.4 ± 0.3 and from 0.6 ± 0.3 to 0.3 ± 0.3, the elevation area (mm2) decreased from 17.0 ± 8.4 to 13.0 ± 7.1 and from 17.0 ± 7.8 to 10.0 ± 5.6, and the maximum peak height (mm) also decreased from 0.10 ± 0.04 to 0.06 ± 0.04 and from 0.10 ± 0.03 to 0.06 ± 0.02 in the MFR and NAFL groups, respectively. Using CineScan, the depth of middle orbital fat (mm) decreased significantly from 10.2 ± 2.2 to 8.0 ± 0.7 and from 9.8 ± 1.1 to 8.0 ± 0.9 and the length of orbital fat significantly decreased from 9.2 ± 1.2 to 7.7 ± 0.7 and from 9.7 ± 1.4 to 7.8 ± 0.6 in the MFR and NAFL groups, respectively. MFR and NAFL therapies were effective for the treatment of BLEs, especially in BLE patients with skin elasticity in addition to tear trough deformity and orbital fat prolapse.

Trial registration number: NCT04237324.

Trial register: ClinicalTrials.gov.

Level of evidence: Level I, therapeutic study.

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来源期刊
CiteScore
2.50
自引率
0.00%
发文量
36
审稿时长
>12 weeks
期刊介绍: A unique journal that focuses on the application of cosmetic laser and light therapies on the skin. The Journal of Cosmetic & Laser Therapy provides a forum for stimulating and up-to-date studies demonstrating the wide range of therapeutic options for clinicians and surgeons involved in cosmetic and dermatological treatment. The journal is aimed at dermatologists, cosmetic surgeons, plastic and facial plastic surgeons, oculoplastic surgeons and all those interested in the rapidly expanding field of cosmetic and laser therapy. Features include: -Cosmetic surgery, including facial rejuvenation, hair removal and skin resurfacing -Use of lasers and other light sources for cosmetic and dermatological treatment -Applications of peeling agents, fillers, injectables, implants and other cosmetic modalities -Topical treatments -Practical tips and safety issues
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