甘油三酯葡萄糖指数与改良甘油三酯葡萄糖指数预测青少年非酒精性脂肪肝的比较

IF 3.9 2区 医学 Q1 PEDIATRICS
Kyungchul Song MD , Goeun Park PhD , Hye Sun Lee PhD , Myeongseob Lee MD , Hae In Lee MD , Han Saem Choi MD , Junghwan Suh MD , Ahreum Kwon MD , Ho-Seong Kim MD, PhD , Hyun Wook Chae MD, PhD
{"title":"甘油三酯葡萄糖指数与改良甘油三酯葡萄糖指数预测青少年非酒精性脂肪肝的比较","authors":"Kyungchul Song MD ,&nbsp;Goeun Park PhD ,&nbsp;Hye Sun Lee PhD ,&nbsp;Myeongseob Lee MD ,&nbsp;Hae In Lee MD ,&nbsp;Han Saem Choi MD ,&nbsp;Junghwan Suh MD ,&nbsp;Ahreum Kwon MD ,&nbsp;Ho-Seong Kim MD, PhD ,&nbsp;Hyun Wook Chae MD, PhD","doi":"10.1016/j.jpeds.2021.11.042","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p><span>To assess the associations between the triglyceride glucose (TyG) index and modified TyG indices with </span>nonalcoholic fatty liver disease (NAFLD) and evaluate their ability as predictors of NAFLD in youths.</p></div><div><h3>Study design</h3><p>We analyzed the cross-sectional data of 3728 individuals aged 10-19 years using the Korea National Health and Nutrition Examination Survey, a nationally representative survey. Logistic regression analysis was performed, and ORs and 95% CIs of tertiles 2 and 3 for each variable for predicting NAFLD were calculated and compared with those of tertile 1 as the reference. Receiver operating characteristic (ROC) curves were plotted to evaluate the ability of each variable for NAFLD prediction.</p></div><div><h3>Results</h3><p>All TyG and modified TyG indices exhibited progressively increased ORs and 95% CIs for NAFLD across all tertiles (all <em>P</em> &lt; .001). In addition, all TyG and modified TyG indices significantly predicted NAFLD through ROC curves. All modified TyG indices were superior to the TyG index for predicting NAFLD in all subjects and in males. Among females, the TyG-waist-to-height ratio was superior to the TyG index, TyG-body mass index (BMI), and TyG-waist circumference (WC), and the TyG-BMI SDS and TyG-WC were superior to the TyG index.</p></div><div><h3>Conclusions</h3><p>The TyG and modified TyG indices are markers for NAFLD prediction in youths, and the modified TyG indices are superior to the TyG index. Modified TyG indices have the potential to be simple and cost-effective markers in screening for NAFLD in youths.</p></div>","PeriodicalId":54774,"journal":{"name":"Journal of Pediatrics","volume":"242 ","pages":"Pages 79-85.e1"},"PeriodicalIF":3.9000,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"15","resultStr":"{\"title\":\"Comparison of the Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict Nonalcoholic Fatty Liver Disease in Youths\",\"authors\":\"Kyungchul Song MD ,&nbsp;Goeun Park PhD ,&nbsp;Hye Sun Lee PhD ,&nbsp;Myeongseob Lee MD ,&nbsp;Hae In Lee MD ,&nbsp;Han Saem Choi MD ,&nbsp;Junghwan Suh MD ,&nbsp;Ahreum Kwon MD ,&nbsp;Ho-Seong Kim MD, PhD ,&nbsp;Hyun Wook Chae MD, PhD\",\"doi\":\"10.1016/j.jpeds.2021.11.042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p><span>To assess the associations between the triglyceride glucose (TyG) index and modified TyG indices with </span>nonalcoholic fatty liver disease (NAFLD) and evaluate their ability as predictors of NAFLD in youths.</p></div><div><h3>Study design</h3><p>We analyzed the cross-sectional data of 3728 individuals aged 10-19 years using the Korea National Health and Nutrition Examination Survey, a nationally representative survey. Logistic regression analysis was performed, and ORs and 95% CIs of tertiles 2 and 3 for each variable for predicting NAFLD were calculated and compared with those of tertile 1 as the reference. Receiver operating characteristic (ROC) curves were plotted to evaluate the ability of each variable for NAFLD prediction.</p></div><div><h3>Results</h3><p>All TyG and modified TyG indices exhibited progressively increased ORs and 95% CIs for NAFLD across all tertiles (all <em>P</em> &lt; .001). In addition, all TyG and modified TyG indices significantly predicted NAFLD through ROC curves. All modified TyG indices were superior to the TyG index for predicting NAFLD in all subjects and in males. Among females, the TyG-waist-to-height ratio was superior to the TyG index, TyG-body mass index (BMI), and TyG-waist circumference (WC), and the TyG-BMI SDS and TyG-WC were superior to the TyG index.</p></div><div><h3>Conclusions</h3><p>The TyG and modified TyG indices are markers for NAFLD prediction in youths, and the modified TyG indices are superior to the TyG index. Modified TyG indices have the potential to be simple and cost-effective markers in screening for NAFLD in youths.</p></div>\",\"PeriodicalId\":54774,\"journal\":{\"name\":\"Journal of Pediatrics\",\"volume\":\"242 \",\"pages\":\"Pages 79-85.e1\"},\"PeriodicalIF\":3.9000,\"publicationDate\":\"2022-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"15\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pediatrics\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022347621011148\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pediatrics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022347621011148","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 15

摘要

目的探讨甘油三酯葡萄糖(TyG)指数和改良TyG指数与青少年非酒精性脂肪肝(NAFLD)的相关性,并评价其作为预测青少年非酒精性脂肪肝(NAFLD)的能力。研究设计我们分析了3728名年龄在10-19岁的人的横断面数据,使用了韩国国家健康和营养检查调查,这是一项具有全国代表性的调查。进行Logistic回归分析,计算各变量预测NAFLD的分位数2和3的or和95% CIs,并与分位数1的or和95% CIs进行比较,作为参考。绘制受试者工作特征(ROC)曲线,评估每个变量预测NAFLD的能力。结果所有TyG和改良TyG指数均显示NAFLD的or值和95% ci值逐渐升高(P <措施)。此外,TyG及修改后的TyG指标均可通过ROC曲线显著预测NAFLD。在所有受试者和男性中,所有修改的TyG指数在预测NAFLD方面都优于TyG指数。在女性中,TyG-腰高比优于TyG指数、TyG-体重指数(BMI)和TyG-腰围(WC), TyG-BMI SDS和TyG-WC优于TyG指数。结论TyG和改良TyG指标是预测青少年NAFLD的指标,改良TyG指标优于TyG指标。改良的TyG指数有潜力成为筛查青少年NAFLD的简单和经济有效的标记物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of the Triglyceride Glucose Index and Modified Triglyceride Glucose Indices to Predict Nonalcoholic Fatty Liver Disease in Youths

Objective

To assess the associations between the triglyceride glucose (TyG) index and modified TyG indices with nonalcoholic fatty liver disease (NAFLD) and evaluate their ability as predictors of NAFLD in youths.

Study design

We analyzed the cross-sectional data of 3728 individuals aged 10-19 years using the Korea National Health and Nutrition Examination Survey, a nationally representative survey. Logistic regression analysis was performed, and ORs and 95% CIs of tertiles 2 and 3 for each variable for predicting NAFLD were calculated and compared with those of tertile 1 as the reference. Receiver operating characteristic (ROC) curves were plotted to evaluate the ability of each variable for NAFLD prediction.

Results

All TyG and modified TyG indices exhibited progressively increased ORs and 95% CIs for NAFLD across all tertiles (all P < .001). In addition, all TyG and modified TyG indices significantly predicted NAFLD through ROC curves. All modified TyG indices were superior to the TyG index for predicting NAFLD in all subjects and in males. Among females, the TyG-waist-to-height ratio was superior to the TyG index, TyG-body mass index (BMI), and TyG-waist circumference (WC), and the TyG-BMI SDS and TyG-WC were superior to the TyG index.

Conclusions

The TyG and modified TyG indices are markers for NAFLD prediction in youths, and the modified TyG indices are superior to the TyG index. Modified TyG indices have the potential to be simple and cost-effective markers in screening for NAFLD in youths.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Pediatrics
Journal of Pediatrics 医学-小儿科
CiteScore
6.00
自引率
2.00%
发文量
696
审稿时长
31 days
期刊介绍: The Journal of Pediatrics is an international peer-reviewed journal that advances pediatric research and serves as a practical guide for pediatricians who manage health and diagnose and treat disorders in infants, children, and adolescents. The Journal publishes original work based on standards of excellence and expert review. The Journal seeks to publish high quality original articles that are immediately applicable to practice (basic science, translational research, evidence-based medicine), brief clinical and laboratory case reports, medical progress, expert commentary, grand rounds, insightful editorials, “classic” physical examinations, and novel insights into clinical and academic pediatric medicine related to every aspect of child health. Published monthly since 1932, The Journal of Pediatrics continues to promote the latest developments in pediatric medicine, child health, policy, and advocacy. Topics covered in The Journal of Pediatrics include, but are not limited to: General Pediatrics Pediatric Subspecialties Adolescent Medicine Allergy and Immunology Cardiology Critical Care Medicine Developmental-Behavioral Medicine Endocrinology Gastroenterology Hematology-Oncology Infectious Diseases Neonatal-Perinatal Medicine Nephrology Neurology Emergency Medicine Pulmonology Rheumatology Genetics Ethics Health Service Research Pediatric Hospitalist Medicine.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信