{"title":"虹膜素与阻塞性睡眠呼吸暂停患者的血压有关","authors":"Xing Wang, Zhengjiao Zhang, Xiaoxin Lan, Keyou Fu, Guanhua Xu, Jingyi Zhao, Haibo Yuan","doi":"10.1155/2021/4717349","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated.</p><p><strong>Purpose: </strong>To investigate the changes of irisin and its relationship with BP in OSA.</p><p><strong>Methods: </strong>72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software.</p><p><strong>Results: </strong>Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (<i>p</i> < 0.05). For BP, significant differences were found between the control group and the other three groups (<i>p</i> < 0.05) and between the quite severe and the other three groups (<i>p</i> ≤ 0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO<sub>2</sub> nadir and SpO<sub>2</sub> nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables.</p><p><strong>Conclusions: </strong>Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":"2021 ","pages":"4717349"},"PeriodicalIF":1.9000,"publicationDate":"2021-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601862/pdf/","citationCount":"0","resultStr":"{\"title\":\"Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients.\",\"authors\":\"Xing Wang, Zhengjiao Zhang, Xiaoxin Lan, Keyou Fu, Guanhua Xu, Jingyi Zhao, Haibo Yuan\",\"doi\":\"10.1155/2021/4717349\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated.</p><p><strong>Purpose: </strong>To investigate the changes of irisin and its relationship with BP in OSA.</p><p><strong>Methods: </strong>72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software.</p><p><strong>Results: </strong>Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (<i>p</i> < 0.05). For BP, significant differences were found between the control group and the other three groups (<i>p</i> < 0.05) and between the quite severe and the other three groups (<i>p</i> ≤ 0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO<sub>2</sub> nadir and SpO<sub>2</sub> nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables.</p><p><strong>Conclusions: </strong>Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.</p>\",\"PeriodicalId\":14132,\"journal\":{\"name\":\"International Journal of Hypertension\",\"volume\":\"2021 \",\"pages\":\"4717349\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2021-11-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601862/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Hypertension\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2021/4717349\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"PERIPHERAL VASCULAR DISEASE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Hypertension","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2021/4717349","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0
摘要
背景：尽管原发性高血压患者约占 95%，但继发性高血压似乎是常见的抵抗性高血压。值得注意的是，众所周知，阻塞性睡眠呼吸暂停（OSA）是继发性高血压的常见病因，其主要特征是肥胖。鸢尾素是肥胖症患者肌肉和脂肪组织之间的纽带，在人体血压调节中发挥着重要作用。目的：研究 OSA 患者虹膜素的变化及其与血压的关系。方法：72 名打鼾患者在进行多导睡眠图（PSG）检查前完成了 Epworth 睡眠量表（ESS）评估。血压为水银血压计三次肱动脉血压的平均值。血清鸢尾素水平通过酶联免疫吸附试验（ELISA）测定。结果用 SPSS 软件进行分析：重度组和相当重度组的鸢尾素高于对照组和非重度组（P < 0.05）。血压方面，对照组与其他三组之间存在显著差异（P < 0.05），重度组与其他三组之间存在显著差异（P ≤ 0.001）。虹膜素与呼吸暂停-低通气指数（AHI）、AHI 与血压、虹膜素水平与血压之间存在正相关。鸢尾素与 SpO2 nadir 和 SpO2 nadir 与血压之间呈负相关。即使在调整了一些肥胖相关变量后，AHI与鸢尾素之间仍存在正相关：结论：虹膜素可作为OSA严重程度的潜在生物标志物，而与肥胖无关，并暗示着高血压的发展。
Irisin Is Correlated with Blood Pressure in Obstructive Sleep Apnea Patients.
Background: Despite approximately 95% primary cases of hypertension, secondary hypertension seems to be common with resistant forms. Notably, obstructive sleep apnea (OSA) is known as a common cause of secondary hypertension and has a major characteristic of obesity. Irisin acts as a link between muscles and adipose tissues in obesity, playing an essential role in human blood pressure (BP) regulation. However, whether irisin is associated with secondary hypertension caused by OSA and how it takes effect essentially have not been elucidated.
Purpose: To investigate the changes of irisin and its relationship with BP in OSA.
Methods: 72 snoring patients finished Epworth Sleep Scale (ESS) evaluation before polysomnography (PSG). BP was the average of three brachial BP values by mercury sphygmomanometer. Serum irisin level was determined by enzyme-linked immunosorbent assay (ELISA). Results were analyzed by SPSS software.
Results: Irisin was higher in the severe and quite severe group than that in control and nonsevere groups (p < 0.05). For BP, significant differences were found between the control group and the other three groups (p < 0.05) and between the quite severe and the other three groups (p ≤ 0.001). Positive correlations were found between irisin and apnea-hypopnea index (AHI), AHI and BP, and irisin level and BP. Negative correlations were between irisin and SpO2 nadir and SpO2 nadir and BP. Positive correlation still existed between AHI and irisin even after adjusting for some obesity-related variables.
Conclusions: Irisin may serve as a potential biomarker for severity of OSA independently of obesity and imply the development of hypertension.
期刊介绍：
International Journal of Hypertension is a peer-reviewed, Open Access journal that provides a forum for clinicians and basic scientists interested in blood pressure regulation and pathophysiology, as well as treatment and prevention of hypertension. The journal publishes original research articles, review articles, and clinical studies on the etiology and risk factors of hypertension, with a special focus on vascular biology, epidemiology, pediatric hypertension, and hypertensive nephropathy.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
