膀胱癌根治性膀胱前列腺切除术时并发前列腺癌特征的肿瘤学影响:一项基于人群的分析

IF 2.7 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Aging Male Pub Date : 2022-12-01 DOI:10.1080/13685538.2022.2040982

Mykyta Kachanov, Malte W Vetterlein, Armin Soave, Pierre I Karakiewicz, Nikolaos Liakos, Thomas Jankowski, Randi M Pose, Mikolaj Mandrek, Margit Fisch, Jorn H Witt, Markus Graefen, Sami-Ramzi Leyh-Bannurah

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引用次数: 1

摘要

目的:本研究的目的是评估老年膀胱癌(BCa)患者行根治性膀胱前列腺切除术(RCP)后并发前列腺癌(PCa)对癌症特异性死亡率(CSM)的影响。材料和方法:在SEER数据库(2004-2015)中，1468例BCa患者接受了RCP治疗，这些患者有组织病理学上的PCa发现。为了解释其他原因死亡率(OCM)，根据预测CSM的PCa特征危险因素，多变量竞争风险回归(CRR)测试了潜在的BCa-CSM差异。结果:CRR分析显示只有以下BCa特征，作为高病理分期的肿瘤(Ta/Tis/T1 [REF.] vs. T2;HR 2.03, 95% CI: 1.16-3.57, p = 0.014 vs. T3;HR 4.32, 95% CI: 2.45-7.61, p p p结论:我们的研究基于最大的人群队列，表明即使在器官受限的BCa患者中，合并前列腺癌作为第二恶性肿瘤并不代表生存的危险因素。

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Oncologic impact of concomitant prostate cancer characteristics at the time of radical cystoprostatectomy for bladder cancer: a population-based analysis.

Objective: The aim of this study was to evaluate the prognostic impact of concomitant prostate cancer (PCa) of the cancer-specific mortality (CSM) in the aging patient's papulation with bladder cancer (BCa) treated with radical cystoprostatectomy (RCP).

Materials and methods: Within the SEER database (2004-2015), 1468 patients were treated with RCP for BCa harboring histopathological PCa findings. To account for other cause mortality (OCM), multivariable competing risk regression (CRR) tested for potential BCa-CSM differences according to PCa characteristics risk factors predicting CSM.

Results: CRR analysis revealed that only following BCa characteristics, as high pathological tumor stages(Ta/Tis/T1 [REF.] vs. T2; HR 2.03, 95% CI: 1.16-3.57, p = 0.014 vs. T3; HR 4.32, 95% CI: 2.45-7.61, p < 0.001 vs. T4; HR 5.06, 95% CI: 2.77-9.22, p < 0.001), as well unfavorable BCa grade IV (Grade I-II [REF.] vs. Grade IV; HR 0.58, 95% CI: 0.35-0.98, p < 0.041) achieved independent predictor status of CSM. With regard to PCa characteristics, none of the covariates yielded independent predictor status of CSM.

Conclusions: Our study, based on the largest population cohort, demonstrates that even in organ-confined BCa patients, concomitant PCa as second malignancy does not represent a risk factor for survival.

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来源期刊

Aging Male 医学-泌尿学与肾脏学

CiteScore

6.40

自引率

3.80%

发文量

审稿时长

>12 weeks

期刊介绍： The Aging Male , the official journal of the International Society for the Study of the Aging Male, is a multidisciplinary publication covering all aspects of male health throughout the aging process. The Journal is a well-recognized and respected resource for anyone interested in keeping up to date with developments in this field. It is published quarterly in one volume per year. The Journal publishes original peer-reviewed research papers as well as review papers and other appropriate educational material that provide researchers with an integrated perspective on this new, emerging specialty. Areas of interest include, but are not limited to: Diagnosis and treatment of late-onset hypogonadism Metabolic syndrome and related conditions Treatment of erectile dysfunction and related disorders Prostate cancer and benign prostate hyperplasia.