源自主胰管的头侧未分化癌伴破骨细胞样巨细胞:1例报告及文献复习。

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Archive of clinical cases Pub Date : 2021-10-27 eCollection Date: 2019-01-01 DOI:10.22551/2019.22.0601.10148
Andreea Rusu, Simona Eliza Giuşcă, Delia Gabriela Ciobanu Apostol, Lidia Ionescu, Irina-Draga Căruntu
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引用次数: 0

摘要

未分化癌伴破骨细胞样巨细胞(UCOGC)是一种导管癌变体,最近报道其生存时间更长,病理组织学包括两种细胞群:单核肿瘤细胞和非肿瘤多核巨细胞。它通常表现为一个大的异质肿瘤,混合有固体囊性成分。肿瘤由导管上皮发展而来,但由于肿瘤的快速生长和相关的坏死变化,通常无法确定上皮变化的顺序。我们报告一例76岁的患者,诊断为起源于主胰管上皮的头侧UCOGC,伴管腔内生长和其他导管肿瘤灶(高级别胰腺上皮内瘤变(PanIN)和常规导管癌)。本病例的特殊之处在于,通过高级别PanIN,在大尺寸肿瘤中发现柱状上皮转化为UCOGC特异性恶性特征-通常在小肿瘤中报道。除了我们的病例,我们也提出了一个简短的文献回顾头侧UCOGC病例报告和病例系列。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review.

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review.

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review.

Cephalic undifferentiated carcinoma with osteoclast-like giant cells arising from the main pancreatic duct: case report and literature review.

Undifferentiated carcinoma with osteoclast-like giant cell (UCOGC) is a ductal carcinoma variant with a recently reported more protracted survival and pathognomonic histology comprising two cell populations: the mononuclear tumoral cells and nontumoral multinucleated giant cells. It usually presents as a large heterogenic tumor with mixed solid-cystic components. The tumor develops from the ductal epithelium but the sequence of epithelial changes is often not identified due to the rapid tumoral growth and associated necrotic changes. We report a case of a 76-year-old patient diagnosed with cephalic UCOGC originating in the epithelium of the main pancreatic duct with endoluminal growth and foci of other ductal neoplasms (high-grade pancreatic intraepithelial neoplasia (PanIN) and conventional ductal carcinoma). The particularity of our case consists in the identification of the columnar epithelium conversion, through high-grade PanIN, into UCOGC specific malignant features, in a large size tumor - aspect usually reported in small tumors. Alongside our case we also present a brief literature review of cephalic UCOGC case reports and case series.

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