香兰素能改善果糖-链脲佐菌素诱导的糖尿病大鼠的葡萄糖稳态，并调节与 2 型糖尿病有关的代谢活动。

IF 2.5 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Archives of Physiology and Biochemistry Pub Date : 2024-04-01 Epub Date: 2021-11-09 DOI:10.1080/13813455.2021.1988981

Veronica F Salau, Ochuko L Erukainure, Kolawole O Olofinsan, Nontokozo Z Msomi, Omamuyovwi M Ijomone, Md Shahidul Islam

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引用次数: 0

摘要

研究目的本研究采用体外、硅学和体内实验模型研究香兰素的抗糖尿病作用：方法：用果糖-链脲佐菌素（STZ）诱导雄性斯普拉格-道利（SD）大鼠患 2 型糖尿病（T2D），然后口服低剂量（150 毫克/千克体重）或高剂量（300 毫克/千克体重）香兰素，干预期为 5 周：结果：香兰素抑制了血糖、血清胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-c）、丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、肌酐、尿素、尿酸的水平，同时升高了血清胰岛素、高密度脂蛋白胆固醇，并同时改善了胰腺β细胞功能、葡萄糖耐量和胰腺形态。它还能提高血清和胰腺组织的 GSH 水平、SOD 和过氧化氢酶活性以及肝糖原水平，同时降低丙二醛水平、α-淀粉酶、脂肪酶、乙酰胆碱酯酶、ATP 酶、ENTPD 酶和 5'-核苷酸酶、葡萄糖-6-磷酸酶、果糖-1,6-二磷酸酶和糖原磷酸化酶活性：结果表明，香兰素对 T2D 及其相关并发症有很强的抗糖尿病作用。

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Vanillin improves glucose homeostasis and modulates metabolic activities linked to type 2 diabetes in fructose-streptozotocin induced diabetic rats.

Objective: This study investigated the antidiabetic effect of vanillin using in vitro, in silico, and in vivo experimental models.

Methodology: Type 2 diabetes (T2D) was induced in male Sprague-Dawley (SD) rats using fructose-streptozotocin (STZ), then orally administered low (150 mg/kg bodyweight) or high (300 mg/kg bodyweight) dose of vanillin for 5 weeks intervention period.

Results: Vanillin suppressed the levels of blood glucose, serum cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), aspartate transaminase (AST), creatinine, urea, uric acid, when elevated serum insulin, HDL-cholesterol, and concomitantly improved pancreatic β-cell function, glucose tolerance, and pancreatic morphology. It also elevated both serum and pancreatic tissue GSH level, SOD and catalase activities, and hepatic glycogen level, while depleting malondialdehyde level, α-amylase, lipase, acetylcholinesterase, ATPase, ENTPDase and 5'-nucleotidase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, and glycogen phosphorylase activities.

Conclusions: The results indicate the potent antidiabetic effect of vanillin against T2D and its associated complications.

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来源期刊

Archives of Physiology and Biochemistry ENDOCRINOLOGY & METABOLISM-PHYSIOLOGY

CiteScore

6.90

自引率

3.30%

发文量

期刊介绍： Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders. The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications. Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics: -Dysregulation of hormone receptors and signal transduction -Contribution of gene variants and gene regulatory processes -Impairment of intermediary metabolism at the cellular level -Secretion and metabolism of peptides and other factors that mediate cellular crosstalk -Therapeutic strategies for managing metabolic diseases Special issues dedicated to topics in the field will be published regularly.