重症监护病房急性肾损伤患者死亡率预测的决策支持系统。

IF 2 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Journal of applied biomedicine Pub Date : 2020-03-01 Epub Date: 2020-02-28 DOI:10.32725/jab.2020.004
Selda Kayaalti, Omer Kayaalti, Bekir Hakan Aksebzeci
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引用次数: 0

摘要

重症监护室(ICU)是医院的一个非常特殊的单位,在这里,医疗保健专业人员提供治疗,然后对患者进行密切随访。从多个角度估计ICU患者的死亡率是至关重要的。本研究的目的是应用分类回归树(CART)算法对ICU急性肾损伤(AKI)患者的血尿素氮、肌酐、血清和尿中性粒细胞明胶酶相关脂钙蛋白(NGAL)、碱性磷酸酶、乳酸脱氢酶(LDH)、γ -谷氨酰转移酶、实验室电解质、血气、平均动脉压,中心静脉压和患者的人口统计学细节。本研究对50例AKI患者进行了ICU随访。本研究还旨在通过Kruskal-Wallis H检验确定用于预测CART死亡率的属性与患者状态之间关系的显著性。CART对预测患者早期死亡率、晚期死亡率和生存率的检测属性的分类准确率、敏感性和特异性分别为90.00%、83.33%和91.67%。经Kruskal-Wallis H试验检查,第7天的尿NGAL和LDH值根据患者状态有较大差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A decision support system for the prediction of mortality in patients with acute kidney injury admitted in intensive care unit.

Intensive care unit (ICU) is a very special unit of a hospital, where healthcare professionals provide treatment and, later, close follow-up to the patients. It is crucial to estimate mortality in ICU patients from many viewpoints. The purpose of this study is to classify the status of patients with acute kidney injury (AKI) in ICU as early mortality, late mortality, and survival by the application of Classification and Regression Trees (CART) algorithm to the patients' attributes such as blood urea nitrogen, creatinine, serum and urine neutrophil gelatinase-associated lipocalin (NGAL), alkaline phosphatase, lactate dehydrogenase (LDH), gamma-glutamyl transferase, laboratory electrolytes, blood gas, mean arterial pressure, central venous pressure and demographic details of patients. This study was conducted 50 patients with AKI who were followed up in the ICU. The study also aims to determine the significance of relationship between the attributes used in the prediction of mortality in CART and patients' status by employing the Kruskal-Wallis H test. The classification accuracy, sensitivity, and specificity of CART for the tested attributes for the prediction of early mortality, late mortality, and survival of patients were 90.00%, 83.33%, and 91.67%, respectively. The values of both urine NGAL and LDH on day 7 showed a considerable difference according to the patients' status after being examined by the Kruskal-Wallis H test.

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来源期刊
Journal of applied biomedicine
Journal of applied biomedicine PHARMACOLOGY & PHARMACY-
CiteScore
2.40
自引率
7.70%
发文量
13
审稿时长
>12 weeks
期刊介绍: Journal of Applied Biomedicine promotes translation of basic biomedical research into clinical investigation, conversion of clinical evidence into practice in all medical fields, and publication of new ideas for conquering human health problems across disciplines. Providing a unique perspective, this international journal publishes peer-reviewed original papers and reviews offering a sensible transfer of basic research to applied clinical medicine. Journal of Applied Biomedicine covers the latest developments in various fields of biomedicine with special attention to cardiology and cardiovascular diseases, genetics, immunology, environmental health, toxicology, neurology and oncology as well as multidisciplinary studies. The views of experts on current advances in nanotechnology and molecular/cell biology will be also considered for publication as long as they have a direct clinical impact on human health. The journal does not accept basic science research or research without significant clinical implications. Manuscripts with innovative ideas and approaches that bridge different fields and show clear perspectives for clinical applications are considered with top priority.
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