糖尿病视网膜病变中的血清镁:相关性有待研究。

IF 2.3 Q2 OPHTHALMOLOGY
Therapeutic Advances in Ophthalmology Pub Date : 2021-12-05 eCollection Date: 2021-01-01 DOI:10.1177/25158414211056385
Koushik Shivakumar, A R Rajalakshmi, Kirti Nath Jha, Swathi Nagarajan, A R Srinivasan, A Lokesh Maran
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引用次数: 0

摘要

背景:镁在葡萄糖代谢中起着至关重要的作用,而低镁血症在糖尿病患者中很常见。目的:确定肾功能正常的 2 型糖尿病患者血清镁水平与视网膜病变之间的关系,并将其与视网膜病变的严重程度联系起来:这项横断面观察性研究在一家半城市三级护理教学医院进行。测定了伴有视网膜病变的 2 型糖尿病(DM)患者(第 1 组)和未伴有视网膜病变的 2 型糖尿病(DM)患者(第 2 组)的临床人口学特征和血清镁水平。血清镁水平与视网膜病变的存在和严重程度相关:结果:在 104 名 2 型糖尿病患者中,50 人患有视网膜病变。年龄较小、病程较长和血糖控制较差(p < 0.05)与视网膜病变有关。视网膜病变患者和无视网膜病变患者的平均血清镁水平分别为 1.63 ± 0.30 mg/dL 和 1.76 ± 0.22 mg/dL (p = 0.029)。血清镁降低与空腹糖升高(p = 0.019)和女性性别(p = 0.037)有关。通过方差分析对有视力威胁的糖尿病视网膜病变(STDR)、非 STDR 和无视网膜病变患者进行比较分析,STDR 患者的血清镁(1.55 ± 0.33 mg/dL)显著较低(p = 0.031):结论:糖尿病视网膜病变患者的血清镁水平较低。结论:糖尿病视网膜病变患者的血清镁水平较低,STDR 患者的血清镁水平低于无 STDR 患者。视力受到威胁的糖尿病视网膜病变患者的血清镁水平明显较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Serum magnesium in diabetic retinopathy: the association needs investigation.

Serum magnesium in diabetic retinopathy: the association needs investigation.

Serum magnesium in diabetic retinopathy: the association needs investigation.

Serum magnesium in diabetic retinopathy: the association needs investigation.

Background: Magnesium has an essential role in glucose metabolism, and hypomagnesaemia is common in diabetes mellitus. However, the relationship between serum magnesium and diabetic retinopathy is poorly understood.

Aim: To determine the association between serum magnesium levels and retinopathy in type 2 diabetic patients with normal renal function and to correlate it with severity of retinopathy.

Methods: This cross-sectional observational study was conducted in a semi-urban tertiary-care teaching hospital. Clinicodemographic profile and serum magnesium levels were determined in patients with type 2 diabetes mellitus (DM) with (group 1) and without (group 2) retinopathy. Serum magnesium levels were correlated with the presence and severity of retinopathy.

Results: Of 104 type 2 DM patients, 50 had retinopathy. Younger age, longer duration of disease and poorer glycaemic control (p < 0.05) were found to be associated with retinopathy. The mean serum magnesium levels in patients with retinopathy and those without retinopathy were 1.63 ± 0.30 mg/dL and 1.76 ± 0.22 mg/dL, respectively (p = 0.029). Reduced serum magnesium was associated with elevated fasting sugars (p = 0.019) and female gender (p = 0.037). On comparative analysis of patients with sight-threatening diabetic retinopathy (STDR), non-STDR and no retinopathy by ANOVA test, patients with STDR had significantly lower serum magnesium (1.55 ± 0.33 mg/dL) (p = 0.031).

Conclusion: Serum magnesium levels were lower in patients with diabetic retinopathy. Patients with STDR had lower serum magnesium compared with those without STDR.

Summary: Serum magnesium, studied extensively for its role in glucose metabolism, was found to be lower in patients with diabetic retinopathy compared with those without retinopathy. Sight-threatening diabetic retinopathy had significantly lower levels of serum magnesium.

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CiteScore
4.50
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