与阿尔茨海默病进展相关的短期和长期功能连接差异

IF 1.4 Q4 CLINICAL NEUROLOGY
Dementia and Geriatric Cognitive Disorders Extra Pub Date : 2021-09-23 eCollection Date: 2021-09-01 DOI:10.1159/000518233
Jaime D Mondragón, Ramesh Marapin, Peter Paul De Deyn, Natasha Maurits
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引用次数: 5

摘要

遗忘性轻度认知障碍(aMCI)进展为阿尔茨海默病(AD)是一个具有高度可变进展率的临床事件,从10-15%到30-34%不等。功能连通性(FC),即空间远程神经生理事件之间的时间相似性,在进展为AD (pMCI)的aMCI患者和未进展为AD(即保持稳定;sMCI)。然而,这些报告有短期随访,并没有提供长期AD进展的见解。方法:79名基线参与者、78名12个月参与者、51名24个月参与者和22名+48个月随访静息状态fMRI参与者均来自阿尔茨海默病神经影像学倡议数据库的aMCI诊断。使用CONN工具箱评估FC。采用局部相关分析和组独立成分分析分别比较sMCI组和pMCI组之间的区域功能耦合和网络间FC。双样本t检验用于检验组间的统计学差异,配对t检验用于评估随时间的认知变化。结果:所有参与者(即66例sMCI和19例pMCI)进行了基线和一年随访的fMRI扫描。19例患者从aMCI进展为AD(12个月时10例,24个月时5例,>48个月时4例),而73例MCI患者保持认知稳定(sMCI)。pMCI和sMCI的认知特征不同。sMCI和pMCI患者之间存在更多的网络间FC而不是区域功能耦合差异。sMCI和pMCI患者的显著性网络(SN)和默认模式网络(DMN)的激活在时间上一直存在差异。讨论:sMCI和pMCI患者具有不同的认知和FC特征。只有pMCI患者表现出不同时间的认知差异。DMN和SN在sMCI和pMCI患者组间多个时刻存在局部相关和网络间FC差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Short- and Long-Term Functional Connectivity Differences Associated with Alzheimer's Disease Progression.

Short- and Long-Term Functional Connectivity Differences Associated with Alzheimer's Disease Progression.

Short- and Long-Term Functional Connectivity Differences Associated with Alzheimer's Disease Progression.

Short- and Long-Term Functional Connectivity Differences Associated with Alzheimer's Disease Progression.

Introduction: Progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD) is a clinical event with highly variable progression rates varying from 10-15% up to 30-34%. Functional connectivity (FC), the temporal similarity between spatially remote neurophysiological events, has previously been reported to differ between aMCI patients who progress to AD (pMCI) and those who do not (i.e., remain stable; sMCI). However, these reports had a short-term follow-up and do not provide insight into long-term AD progression.

Methods: Seventy-nine participants with a baseline and 78 with a 12-month, 51 with a 24-month, and 22 with a +48-month follow-up resting-state fMRI with aMCI diagnosis from the Alzheimer's Disease Neuroimaging Initiative database were included. FC was assessed using the CONN toolbox. Local correlation and group independent component analysis were utilized to compare regional functional coupling and between-network FC, respectively, between sMCI and pMCI groups. Two-sample t tests were used to test for statistically significant differences between groups, and paired t-tests were used to assess cognitive changes over time.

Results: All participants (i.e., 66 sMCI and 19 pMCI) had a baseline and a year follow-up fMRI scan. Progression from aMCI to AD occurred in 19 patients (10 at 12 months, 5 at 24 months, and 4 at >48 months), while 73 MCI patients remained cognitively stable (sMCI). The pMCI and sMCI cognitive profiles were different. More between-network FC than regional functional coupling differences were present between sMCI and pMCI patients. Activation in the salience network (SN) and the default mode network (DMN) was consistently different between sMCI and pMCI patients across time.

Discussion: sMCI and pMCI patients have different cognitive and FC profiles. Only pMCI patients showed cognitive differences across time. The DMN and SN showed local correlation and between-network FC differences between the sMCI and pMCI patient groups at multiple moments in time.

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来源期刊
Dementia and Geriatric Cognitive Disorders Extra
Dementia and Geriatric Cognitive Disorders Extra Medicine-Psychiatry and Mental Health
CiteScore
4.30
自引率
0.00%
发文量
18
审稿时长
9 weeks
期刊介绍: This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
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