Hediyeh Baradaran, Alen Delic, J Scott McNally, Matthew Alexander, Jennifer J Majersik, Dennis L Parker, Adam de Havenon
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引用次数: 0
摘要
简介我们在《社区动脉粥样硬化风险研究》（Atherosclerosis Risk in the Community）中评估了衡量动脉僵化程度的颈动脉顺应性与 20 年后海马旁体积（PHV）和海马体积（HV）之间的关系：我们纳入了在第 1 次就诊（1987-1989 年）时测量过颈总动脉顺应性、在第 5 次就诊（2011-2013 年）时进行过脑核磁共振成像测量的参与者。主要结果是双侧 PHV 和 HV 的汇总结果。我们建立了线性回归模型，对年龄、性别、血管风险因素和脑总容量进行了调整：在 614 名参与者中，较高的顺应性与较高的 PHV（R = 0.218[0.144-0.291], p < 0.001）和 HV（R = 0.181[0.105-0.255, p < 0.001]）相关。在对混杂因素进行调整后，两者之间的关系呈线性且显著。在随访磁共振成像时，30 名痴呆症患者的 PHV 和 HV 低于非痴呆症患者（分别为 p < 0.001 和 p < 0.001）：结论：20年后测量颈动脉顺应性与较高的PHV和HV相关，进一步证实了动脉僵化与认知能力下降之间的联系。
Carotid Compliance and Parahippocampal and Hippocampal Volume over a 20-Year Period.
Introduction: We evaluated the association between carotid compliance, a measure of arterial stiffness, to parahippocampal volume (PHV) and hippocampal volume (HV) over 20 years later in the Atherosclerosis Risk in the Community study.
Methods: We included participants with common carotid compliance measurements at visit 1 (1987-1989) and volumetric brain MRI at visit 5 (2011-2013). The primary outcomes are pooled bilateral PHV and HV. We performed linear regression models adjusting for age, sex, vascular risk factors, and total brain volume.
Results: Of the 614 participants, higher compliance was correlated with higher PHV (R = 0.218[0.144-0.291], p < 0.001) and HV (R = 0.181 [0.105-0.255, p < 0.001]). The association was linear and significant after adjusting for confounders. At follow-up MRI, 30 patients with dementia had lower PHV and HV than patients without dementia (p < 0.001 and p < 0.001, respectively).
Conclusion: Carotid compliance is associated with higher PHV and HV when measured 20 years later, further supporting the link between arterial stiffness and cognitive decline.
期刊介绍：
This open access and online-only journal publishes original articles covering the entire spectrum of cognitive dysfunction such as Alzheimer’s and Parkinson’s disease, Huntington’s chorea and other neurodegenerative diseases. The journal draws from diverse related research disciplines such as psychogeriatrics, neuropsychology, clinical neurology, morphology, physiology, genetic molecular biology, pathology, biochemistry, immunology, pharmacology and pharmaceutics. Strong emphasis is placed on the publication of research findings from animal studies which are complemented by clinical and therapeutic experience to give an overall appreciation of the field. Dementia and Geriatric Cognitive Disorders Extra provides additional contents based on reviewed and accepted submissions to the main journal Dementia and Geriatric Cognitive Disorders Extra .
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