杉木素和维生素C对二嗪酮所致大鼠心肌损伤的心脏保护和抗氧化作用。

Environmental analysis, health and toxicology Pub Date : 2022-03-01 Epub Date: 2022-02-03 DOI:10.5620/eaht.2022002
Shahad Mohammed Najeb, Ausama Ayob Jaccob, Muhsin S G Al-Moziel, Hayder Mohammed Abdulhameed
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引用次数: 5

摘要

在伊拉克,过度暴露于杀虫剂越来越难以控制,本研究的目的是评估杉木素和维生素c对二嗪农诱导的大鼠心肌损伤的可能改善作用。雌性大鼠36只,随机分为6组,每组6只。组1给予重氮酮20 mg/kg,灌胃30 d。2组在口服二嗪酮(20 mg/kg)前,给予紫杉醇(25 mg/kg)和维生素C (100 mg/kg),每日灌胃,连续30 d。第3组和第4组分别给予taxifoline (25 mg/kg)和维生素C (100 mg/kg),分别灌胃30 d,再给药重氮酮(20 mg/kg)。5组作为对照1,给予紫杉醇素(25 mg/kg)与维生素C (100 mg/kg)联合给药,每天灌胃,连用30 d。最后一组,第6组作为对照2,给药二嗪农。测定大鼠体重、饮水量和食量,观察和记录大鼠一般生命体征。实验结束时,处死大鼠,取血生化分析,取心进行谷胱甘肽过氧化物酶检测及病理评价。除第1组外,所有治疗组和对照组体重均显著增加。1组大鼠肌钙蛋白、LDH、AST、ALT水平显著升高,表明心脏存在缺血和损伤。taxifolin和维生素C联合治疗将其水平显著降低到与对照组相当的浓度。这一发现得到组织病理学观察的支持。此外,本研究表明,二嗪农显著恶化了血脂水平,杉木素和维生素C联合使用导致血脂水平显著改善,谷胱甘肽过氧化物酶值升高,抗氧化水平显著改善。亚急性给药杉木素和维生素C对二嗪嗪诱导的心肌损伤具有心脏保护作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats.

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats.

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats.

Cardioprotective and antioxidant effects of taxifolin and vitamin C against diazinone-induced myocardial injury in rats.

In Iraq, excessive exposure to insecticides is increasingly becoming uncontrollable, the objective of this work was to assess the possible ameliorative role of taxifolin and vitamin c against diazinon-induced myocardial injury in rats. 36 sprague female rats divided into 6 groups of 6 rats each. Group 1 received diazinone 20 mg/kg gavaged for 30 days. Group 2 received taxifolin (25 mg/kg) and vitamin C (100 mg /kg) co-administered together and gavaged daily for 30 days before oral diazinone (20 mg/kg). Group 3 and group 4 were treated with taxifoline (25 mg/kg) and vitamin C (100 mg /kg) respectively, gavaged separately for 30 days before diazinone (20 mg/kg) administration. group 5 was considered as control 1 received taxifolin (25 mg/kg) and vitamin C (100 mg /kg) co-administered together and gavaged daily for 30 days. The last group, group 6 considered as control 2 which received vehicle of diazinon. Rats' weights, water and food intake were measured and the general vital signs of rats were observed and noted. At the end of study, rats are sacrificed, blood withdrawn for biochemical analysis and heart were excised for glutathione peroxidase and pathological evaluation. Significant increase in body weights in all treated and control groups except group 1. Troponin, LDH, AST and ALT levels were significantly increased in group 1 revealing the existence of ischemia and damage in hearts. Treatment with taxifolin and vitamin C combination reduced their levels significantly to concentrations comparable to that in the control groups. Such finding supported by histopathological observation. Moreover, this study showed that diazinon administration significantly deteriorated lipid profile, co-administration of taxifolin and vitamin C was resulted in a significant improvement in lipid profile associated with increased in glutathione peroxidase values showing significant improvement in antioxidant levels. Sub-acute administration of pharmacological doses of taxifolin and vitamin C exerts cardioprotective effects against diazinon-induced myocardial injury in rats.

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