抗坏血酸负载聚乙烯醇/纤维素纳米纤维水凝胶作为3D打印材料的前体

IF 8.1 1区 工程技术 Q1 MATERIALS SCIENCE, BIOMATERIALS
Hossein Baniasadi , Zahraalsadat Madani , Rubina Ajdary , Orlando J. Rojas , Jukka Seppälä
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引用次数: 28

摘要

我们提出了一种简单的方法来处理含有聚乙烯醇和纤维素纳米纤维(PVA/CNF)的水凝胶,通过直接墨水书写(DIW)制备体积结构。CNF在水性聚乙烯醇悬浮液中的存在,赋予了流变学剖面,适用于预先设计的形状的挤压和凝固。混合油墨的粘弹性特性可以精确控制可加工性和形状保持,例如,高保真度的多层晶格结构就证明了这一点。经过冻干后,获得的3d打印水凝胶呈现出非常高的孔隙率,具有开放且相互连接的孔隙,允许高吸水能力(高达1600%)。复合3d打印材料的机械强度与软组织相匹配,为皮肤应用开辟了机会。因此,载药样品显示抗氧化剂(抗坏血酸)在23°C(~80%, 8小时)的PBS缓冲介质中被控制和有效地递送。总之,PVA/CNF水凝胶被引入作为具有优异物理和机械特性的3d晶格几何形状的合适前体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials

Ascorbic acid-loaded polyvinyl alcohol/cellulose nanofibril hydrogels as precursors for 3D printed materials

We proposed a simple method to process hydrogels containing polyvinyl alcohol and cellulose nanofibrils (PVA/CNF) to prepare volumetric architectures by direct ink writing (DIW). The presence of CNF in the aqueous PVA suspensions conferred rheology profiles that were suitable for extrusion and solidification in pre-designed shapes. The viscoelastic behavior of the hybrid inks enabled precise control on processability and shape retention, for instance, as demonstrated in multilayered lattice structures of high fidelity. After lyophilization, the obtained 3D-printed hydrogels presented a very high porosity, with open and interconnected pores, allowing a high-water uptake capacity (up to 1600%). The mechanical strength of the composite 3D-printed materials matched those of soft tissues, opening opportunities for skin applications. As such, drug-loaded samples revealed a controlled and efficient delivery of an antioxidant (ascorbic acid) in PBS buffer media at 23 °C (~80% for 8 h). Altogether, PVA/CNF hydrogels were introduced as suitable precursors of 3D-lattice geometries with excellent physical and mechanical characteristics.

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来源期刊
CiteScore
12.60
自引率
0.00%
发文量
28
审稿时长
3.3 months
期刊介绍: Materials Today is a community committed to fostering the creation and sharing of knowledge and experience in materials science. With the support of Elsevier, this community publishes high-impact peer-reviewed journals, organizes academic conferences, and conducts educational webinars, among other initiatives. It serves as a hub for advancing materials science and facilitating collaboration within the scientific community.
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