"增强 "机械传感:内皮细胞对血流反应中的增强子和增强子衍生的长非编码 RNA。

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology
Current topics in membranes Pub Date : 2021-01-01 Epub Date: 2021-09-21 DOI:10.1016/bs.ctm.2021.08.002
Zhen Bouman Chen, Xuejing Liu, Aleysha T Chen
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引用次数: 0

摘要

内皮细胞(ECs)具有独特的定位和战略地位,构成了血管壁的内衬,是人体面积最大的细胞表面。内皮细胞对机械信号(尤其是剪切应力)的动态感应和反应对维持血管平衡至关重要。众所周知,动脉树中动脉粥样硬化保护区与动脉粥样硬化易发区相关的不同流动模式会导致不同的 EC 功能表型和不同的转录组特征。越来越多的证据表明,非编码基因组在心血管细胞生物学中起着重要的综合调控作用。特别是,最近的研究已开始揭示增强子和增强子衍生转录本在血流调控的心血管细胞基因表达和功能中的重要性。在本小视图中,我们将总结这一领域的研究,并讨论支持增强子和增强子(衍生)长非编码 RNAs(elncRNAs)在欧共体机械传感中新出现的重要性的实例,重点关注欧共体的流动响应转录。最后,我们将从不同角度探讨这些新型调控因子在心肌机械生物学中的作用,并讨论有待解决的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
"Enhancing" mechanosensing: Enhancers and enhancer-derived long non-coding RNAs in endothelial response to flow.

Endothelial cells (ECs), uniquely localized and strategically forming the inner lining of vascular wall, constitute the largest cell surface by area in the human body. The dynamic sensing and response of ECs to mechanical cues, especially shear stress, is crucial for maintenance of vascular homeostasis. It is well recognized that different flow patterns associated with atheroprotective vs atheroprone regions in the arterial tree, result in distinct EC functional phenotypes with differential transcriptome profiles. Mounting evidence has demonstrated an integrative and essential regulatory role of non-coding genome in EC biology. In particular, recent studies have begun to reveal the importance of enhancers and enhancer-derived transcripts in flow-regulated EC gene expression and function. In this minireview, we summarize studies in this area and discuss examples in support of the emerging importance of enhancers and enhancer(-derived) long non-coding RNAs (elncRNAs) in EC mechanosensing, with a focus on flow-responsive EC transcription. Finally, we will provide perspective and discuss standing questions to elucidate the role of these novel regulators in EC mechanobiology.

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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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