sFlt-1/PlGF比值对双胎先兆子痫的预测价值:一项回顾性研究

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2021-11-01 Epub Date: 2021-10-26 DOI:10.1080/10641955.2021.1987455

Satoshi Shinohara, Rei Sunami, Mayuko Kasai, Genki Yasuda, Yuzo Uchida

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引用次数: 5

摘要

目的:探讨可溶性fms样酪氨酸激酶1 (sFlt-1)/胎盘生长因子(PlGF)比值对双胎妊娠4周内子痫前期(PE)的预测作用。方法:78例妊娠28 + 0 ~ 30 + 6周血清血管生成标志物测定的妇女入选。采用受体工作特征曲线确定sFlt-1/PlGF比值阈值，预测PE。结果:sFlt-1/PlGF比值的临界值为22.2，预测4周内存在PE。结论:sFlt-1/PlGF比值≤22.2可能预示双胎妊娠4周内PE缺失。

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Predictive value of the sFlt-1/PlGF ratio for preeclampsia in twin pregnancies: a retrospective study.

Objective: This study aimed to investigate the efficiency of the soluble Fms-like tyrosine kinase 1 (sFlt-1)/placental growth factor (PlGF) ratio in predicting preeclampsia (PE) within 4 weeks in twin pregnancies.Methods: Seventy-eight women with serum angiogenic markers measured at 28 + 0 to 30 + 6 weeks of gestation were enrolled. A receiver-operating characteristic curve was used to determine the sFlt-1/PlGF ratio threshold to predict PE.Results: A cutoff value for the sFlt-1/PlGF ratio of 22.2 predicted PE presence within 4 weeks.Conclusion: An sFlt-1/PlGF ratio of ≤22.2 is potentially indicative of PE absence within 4 weeks in twin pregnancies.

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.