Hai Duc Nguyen, Ngoc Minh Hong Hoang, Myeonghee Ko, Dongjin Seo, Shinhyun Kim, Won Hee Jo, Jung-Woo Bae, Min-Sun Kim
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Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis.</p><p><strong>Results: </strong>A total of 36 comparisons out of 29 studies (3 RCTs and 26 case controls) focusing on NDs (including Parkinson's disease, Alzheimer's disease, Huntington's disease [HD], multiple sclerosis [MS], and epilepsy) were reported. The meta-analysis showed that there was no statistically significant difference in serum PRL levels between patients with NDs and healthy controls (SMD = 0.40, 95% CI: -0.16 to 0.96, p = 0.16). Subgroup analysis showed that serum PRL levels in patients with HD and MS were higher than those of healthy controls. Furthermore, patients with NDs aged <45 years had higher serum PRL levels (SMD = 0.97, 95% CI: 0.16-1.78, p = 0.018) than healthy controls. High serum PRL levels were found in subgroups such as the microenzymatic method, Asia, and the Americas.</p><p><strong>Conclusions: </strong>Our meta-analysis showed serum PRL levels in patients with HD and MS were significantly higher than those in healthy controls. Serum PRL levels were associated with age, region, and detection method. 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引用次数: 9
摘要
催乳素(PRL)具有炎症和抗炎特性,也被认为在神经退行性疾病(NDs)的发病机制中起重要作用。然而,NDs患者的血清PRL水平在研究文献中并不一致。目的:探讨NDs患者血清PRL水平。方法:检索截至2020年12月31日的MEDLINE、Embase、Cochrane Library数据库、clinicaltrials.gov、Web of Science、Google Scholar等电子数据库及文献参考书目。采用固定效应或随机效应模型分析计算95%置信区间(CI)的合并标准平均差(SMD)。结果:29项研究(3项rct和26例对照)中,共报道了36项比较,重点是NDs(包括帕金森病、阿尔茨海默病、亨廷顿病[HD]、多发性硬化症[MS]和癫痫)。meta分析显示,NDs患者与健康对照组血清PRL水平无统计学差异(SMD = 0.40, 95% CI: -0.16 ~ 0.96, p = 0.16)。亚组分析显示,HD和MS患者血清PRL水平高于健康对照组。结论:我们的荟萃分析显示,HD和MS患者的血清PRL水平显著高于健康对照组。血清PRL水平与年龄、地区、检测方法相关。需要使用更统一的检测方法进行其他更大样本的研究来证实我们的结果。
Association between Serum Prolactin Levels and Neurodegenerative Diseases: Systematic Review and Meta-Analysis.
Introduction: Prolactin (PRL) exerts inflammatory and anti-inflammatory properties and is also thought to play an important role in the pathogenesis of neurodegenerative diseases (NDs). However, serum PRL levels in patients with NDs were inconsistent in the research literature.
Objective: We aimed to assess the serum PRL levels in patients with NDs.
Methods: Electronic databases, including MEDLINE, Embase, Cochrane Library database, clinicaltrials.gov, Web of Science, and Google Scholar, and reference lists of articles were searched up to December 31, 2020. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by fixed-effect or random-effect model analysis.
Results: A total of 36 comparisons out of 29 studies (3 RCTs and 26 case controls) focusing on NDs (including Parkinson's disease, Alzheimer's disease, Huntington's disease [HD], multiple sclerosis [MS], and epilepsy) were reported. The meta-analysis showed that there was no statistically significant difference in serum PRL levels between patients with NDs and healthy controls (SMD = 0.40, 95% CI: -0.16 to 0.96, p = 0.16). Subgroup analysis showed that serum PRL levels in patients with HD and MS were higher than those of healthy controls. Furthermore, patients with NDs aged <45 years had higher serum PRL levels (SMD = 0.97, 95% CI: 0.16-1.78, p = 0.018) than healthy controls. High serum PRL levels were found in subgroups such as the microenzymatic method, Asia, and the Americas.
Conclusions: Our meta-analysis showed serum PRL levels in patients with HD and MS were significantly higher than those in healthy controls. Serum PRL levels were associated with age, region, and detection method. Other larger sample studies using more uniform detection methods are necessary to confirm our results.
期刊介绍:
The rapidly expanding area of research known as neuroimmunomodulation explores the way in which the nervous system interacts with the immune system via neural, hormonal, and paracrine actions. Encompassing both basic and clinical research, ''Neuroimmunomodulation'' reports on all aspects of these interactions. Basic investigations consider all neural and humoral networks from molecular genetics through cell regulation to integrative systems of the body. The journal also aims to clarify the basic mechanisms involved in the pathogenesis of the CNS pathology in AIDS patients and in various neurodegenerative diseases. Although primarily devoted to research articles, timely reviews are published on a regular basis.