哺乳动物机械激活离子通道的多种生理功能。

IF 2.9 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
ACS Earth and Space Chemistry Pub Date : 2022-02-10 Epub Date: 2021-10-12 DOI:10.1146/annurev-physiol-060721-100935
Kate Poole
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引用次数: 12

摘要

哺乳动物生理的许多方面都是由机械调节的。一组可以介导机械转导的分子是机械激活的离子通道。这些离子型力传感器由机械输入直接激活,导致离子通量穿过质膜。虽然有很多研究关注机械激活离子通道在触觉和听觉中的作用,但最近的数据强调了这些分子在哺乳动物细胞中的广泛表达模式。机械激活通道的破坏已被证明会影响(a)机械反应性结构的发展,(b)急性机械传感,以及(c)多种组织类型中机械驱动的稳态维持。受这些分子影响的过程的多样性突出了机械激活离子通道在哺乳动物生理学中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Diverse Physiological Functions of Mechanically Activated Ion Channels in Mammals.
Many aspects of mammalian physiology are mechanically regulated. One set of molecules that can mediate mechanotransduction are the mechanically activated ion channels. These ionotropic force sensors are directly activated by mechanical inputs, resulting in ionic flux across the plasma membrane. While there has been much research focus on the role of mechanically activated ion channels in touch sensation and hearing, recent data have highlighted the broad expression pattern of these molecules in mammalian cells. Disruption of mechanically activated channels has been shown to impact (a) the development of mechanoresponsive structures, (b) acute mechanical sensing, and (c) mechanically driven homeostatic maintenance in multiple tissue types. The diversity of processes impacted by these molecules highlights the importance of mechanically activated ion channels in mammalian physiology. Expected final online publication date for the Annual Review of Physiology, Volume 84 is February 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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来源期刊
ACS Earth and Space Chemistry
ACS Earth and Space Chemistry Earth and Planetary Sciences-Geochemistry and Petrology
CiteScore
5.30
自引率
11.80%
发文量
249
期刊介绍: The scope of ACS Earth and Space Chemistry includes the application of analytical, experimental and theoretical chemistry to investigate research questions relevant to the Earth and Space. The journal encompasses the highly interdisciplinary nature of research in this area, while emphasizing chemistry and chemical research tools as the unifying theme. The journal publishes broadly in the domains of high- and low-temperature geochemistry, atmospheric chemistry, marine chemistry, planetary chemistry, astrochemistry, and analytical geochemistry. ACS Earth and Space Chemistry publishes Articles, Letters, Reviews, and Features to provide flexible formats to readily communicate all aspects of research in these fields.
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