造血的炎症调节:将训练免疫和克隆造血与慢性疾病联系起来。

IF 15.7 1区 医学 Q1 PHYSIOLOGY
Annual review of physiology Pub Date : 2022-02-10 Epub Date: 2021-10-06 DOI:10.1146/annurev-physiol-052521-013627
Triantafyllos Chavakis, Ben Wielockx, George Hajishengallis
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引用次数: 14

摘要

长期以来,炎症适应性造血干细胞和祖细胞(HSPCs)一直被认为是紧急骨髓生成的关键驱动因素,从而使骨髓能够满足各种应激条件下(如全身性感染、炎症或骨髓抑制性损伤)对骨髓细胞生成的高需求。近年来,HSPC的适应与长期训练免疫的诱导和不确定电位克隆造血(CHIP)的出现有关。训练免疫具有环境依赖效应,在感染和肿瘤中具有保护作用,但在慢性炎症性疾病中可能有害,CHIP增加了血液肿瘤疾病和心脏代谢病理的风险。这篇综述的重点是HSPC在上述过程中的炎症调节,并讨论了HSPC功能的调节如何导致新的治疗干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders.

Inflammation-adapted hematopoietic stem and progenitor cells (HSPCs) have long been appreciated as key drivers of emergency myelopoiesis, thereby enabling the bone marrow to meet the elevated demand for myeloid cell generation under various stress conditions, such as systemic infection, inflammation, or myelosuppressive insults. In recent years, HSPC adaptations were associated with potential involvement in the induction of long-lived trained immunity and the emergence of clonal hematopoiesis of indeterminate potential (CHIP). Whereas trained immunity has context-dependent effects, protective in infections and tumors but potentially detrimental in chronic inflammatory diseases, CHIP increases the risk for hematological neoplastic disorders and cardiometabolic pathologies. This review focuses on the inflammatory regulation of HSPCs in the aforementioned processes and discusses how modulation of HSPC function could lead to novel therapeutic interventions.

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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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