{"title":"利用生物信息学分析鉴定帕金森病潜在核心基因。","authors":"Wei Quan, Jia Li, Xiya Jin, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen","doi":"10.1155/2021/1690341","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to explore new core genes related to the occurrence of Parkinson's disease (PD) and core genes that can lead to the progression of PD.</p><p><strong>Methods: </strong>The expression profile data of GSE42966, which contained six substantia nigra tissues isolated from normal individuals and nine substantia nigra tissues isolated from patients with PD, were obtained from Gene Expression Omnibus. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. We then identified 10 hub genes and analyzed their expression in different Braak stages.</p><p><strong>Results: </strong>A total of 773 DEGs were identified that were significantly enriched in metabolic pathways. Ten hub genes were identified through the PPI network, namely, <i>GNG3</i>, <i>MAPK1</i>, <i>FPR1</i>, <i>ATP5B</i>, <i>GNG2</i>, <i>PRKACA</i>, <i>HRAS</i>, <i>HSPA8</i>, <i>PSAP</i>, and <i>GABBR2</i>. The expression of <i>HRAS</i> was different in patients with PD with Braak stages 3 and 4.</p><p><strong>Conclusion: </strong>These 10 hub genes and the metabolic pathways they are enriched in may be involved in the pathogenesis of PD. <i>HRAS</i> may have potential value in predicting the progression of PD.</p>","PeriodicalId":19907,"journal":{"name":"Parkinson's Disease","volume":" ","pages":"1690341"},"PeriodicalIF":2.1000,"publicationDate":"2021-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464436/pdf/","citationCount":"8","resultStr":"{\"title\":\"Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis.\",\"authors\":\"Wei Quan, Jia Li, Xiya Jin, Li Liu, Qinghui Zhang, Yidan Qin, Xiaochen Pei, Jiajun Chen\",\"doi\":\"10.1155/2021/1690341\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>This study aimed to explore new core genes related to the occurrence of Parkinson's disease (PD) and core genes that can lead to the progression of PD.</p><p><strong>Methods: </strong>The expression profile data of GSE42966, which contained six substantia nigra tissues isolated from normal individuals and nine substantia nigra tissues isolated from patients with PD, were obtained from Gene Expression Omnibus. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. We then identified 10 hub genes and analyzed their expression in different Braak stages.</p><p><strong>Results: </strong>A total of 773 DEGs were identified that were significantly enriched in metabolic pathways. Ten hub genes were identified through the PPI network, namely, <i>GNG3</i>, <i>MAPK1</i>, <i>FPR1</i>, <i>ATP5B</i>, <i>GNG2</i>, <i>PRKACA</i>, <i>HRAS</i>, <i>HSPA8</i>, <i>PSAP</i>, and <i>GABBR2</i>. The expression of <i>HRAS</i> was different in patients with PD with Braak stages 3 and 4.</p><p><strong>Conclusion: </strong>These 10 hub genes and the metabolic pathways they are enriched in may be involved in the pathogenesis of PD. <i>HRAS</i> may have potential value in predicting the progression of PD.</p>\",\"PeriodicalId\":19907,\"journal\":{\"name\":\"Parkinson's Disease\",\"volume\":\" \",\"pages\":\"1690341\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2021-09-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8464436/pdf/\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Parkinson's Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1155/2021/1690341\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Parkinson's Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1155/2021/1690341","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis.
Purpose: This study aimed to explore new core genes related to the occurrence of Parkinson's disease (PD) and core genes that can lead to the progression of PD.
Methods: The expression profile data of GSE42966, which contained six substantia nigra tissues isolated from normal individuals and nine substantia nigra tissues isolated from patients with PD, were obtained from Gene Expression Omnibus. Differentially expressed genes (DEGs) were identified, followed by functional enrichment analysis and protein-protein interaction (PPI) network construction. We then identified 10 hub genes and analyzed their expression in different Braak stages.
Results: A total of 773 DEGs were identified that were significantly enriched in metabolic pathways. Ten hub genes were identified through the PPI network, namely, GNG3, MAPK1, FPR1, ATP5B, GNG2, PRKACA, HRAS, HSPA8, PSAP, and GABBR2. The expression of HRAS was different in patients with PD with Braak stages 3 and 4.
Conclusion: These 10 hub genes and the metabolic pathways they are enriched in may be involved in the pathogenesis of PD. HRAS may have potential value in predicting the progression of PD.
期刊介绍：
Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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