Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts, Ashok Agrawal, Ralf Henkel, Alia A Al-Hadi, Hasan Burjaq, Alia Alattar, Kareim Khalafalla, Ahmad Majzoub
{"title":"不明原因不孕症中父亲年龄对胞浆内单精子注射结果的影响。","authors":"Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts, Ashok Agrawal, Ralf Henkel, Alia A Al-Hadi, Hasan Burjaq, Alia Alattar, Kareim Khalafalla, Ahmad Majzoub","doi":"10.1080/2090598X.2021.1955553","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>: To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility.</p><p><strong>Subjects and methods: </strong>: This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential).</p><p><strong>Results: </strong>: We found that final pregnancy outcomes including clinical pregnancy rate (<i>P</i> = 0.231), live-birth rate (<i>P</i> = 0.143), and miscarriage rates (<i>P</i> = 0.466) were not significantly different between the two age groups. Normal fertilisation (<i>P</i> = 0.01) and cleavage rate after ICSI (<i>P</i> = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (<i>P</i> = 0.041).</p><p><strong>Conclusions: </strong>: Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.</p>","PeriodicalId":8113,"journal":{"name":"Arab Journal of Urology","volume":"19 3","pages":"274-280"},"PeriodicalIF":1.3000,"publicationDate":"2021-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/2090598X.2021.1955553","citationCount":"0","resultStr":"{\"title\":\"The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility.\",\"authors\":\"Haitham Elbardisi, Mohamed Arafa, Neha Singh, Bridget Betts, Ashok Agrawal, Ralf Henkel, Alia A Al-Hadi, Hasan Burjaq, Alia Alattar, Kareim Khalafalla, Ahmad Majzoub\",\"doi\":\"10.1080/2090598X.2021.1955553\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>: To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility.</p><p><strong>Subjects and methods: </strong>: This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential).</p><p><strong>Results: </strong>: We found that final pregnancy outcomes including clinical pregnancy rate (<i>P</i> = 0.231), live-birth rate (<i>P</i> = 0.143), and miscarriage rates (<i>P</i> = 0.466) were not significantly different between the two age groups. Normal fertilisation (<i>P</i> = 0.01) and cleavage rate after ICSI (<i>P</i> = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (<i>P</i> = 0.041).</p><p><strong>Conclusions: </strong>: Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.</p>\",\"PeriodicalId\":8113,\"journal\":{\"name\":\"Arab Journal of Urology\",\"volume\":\"19 3\",\"pages\":\"274-280\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2021-07-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/2090598X.2021.1955553\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arab Journal of Urology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/2090598X.2021.1955553\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q3\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arab Journal of Urology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/2090598X.2021.1955553","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
The effect of paternal age on intracytoplasmic sperm injection outcome in unexplained infertility.
Objective: : To examine the effect of paternal age on intracytoplasmic sperm injection (ICSI) outcomes in unexplained infertility.
Subjects and methods: : This retrospective study, done at the Hamad Medical Corporation, Doha, Qatar screened infertile couples who underwent ICSI between 2014 and 2019 for the inclusion and exclusion criteria defining 'unexplained infertility'. Couples recruited were allocated into two groups: Group A (paternal age <35 years) and Group B (paternal age ≥35 years). Baseline characteristics, investigations including semen and advanced sperm function tests and ICSI records were compared for primary outcomes such as fertilisation, cleavage, clinical pregnancy, miscarriage and live birth; and secondary outcomes such as semen parameters and advanced sperm functions (DNA fragmentation index and oxidation reduction potential).
Results: : We found that final pregnancy outcomes including clinical pregnancy rate (P = 0.231), live-birth rate (P = 0.143), and miscarriage rates (P = 0.466) were not significantly different between the two age groups. Normal fertilisation (P = 0.01) and cleavage rate after ICSI (P = 0.001) were statistically significant when the age groups were compared. Also, normal sperm morphology was found to be significantly different (P = 0.041).
Conclusions: : Advanced paternal age affects sperm morphology, fertilisation and embryo cleavage in ICSI but does not appear to affect clinical pregnancy, miscarriage or live-birth rates. ICSI appears to be a valid fertility treatment option in advancing paternal age.
期刊介绍：
The Arab Journal of Urology is a peer-reviewed journal that strives to provide a high standard of research and clinical material to the widest possible urological community worldwide. The journal encompasses all aspects of urology including: urological oncology, urological reconstructive surgery, urodynamics, female urology, pediatric urology, endourology, transplantation, erectile dysfunction, and urinary infections and inflammations. The journal provides reviews, original articles, editorials, surgical techniques, cases reports and correspondence. Urologists, oncologists, pathologists, radiologists and scientists are invited to submit their contributions to make the Arab Journal of Urology a viable international forum for the practical, timely and state-of-the-art clinical urology and basic urological research.
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