9例宫颈神经内分泌癌的临床病理分析

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2021-09-16 eCollection Date: 2021-01-01 DOI:10.1155/2021/8290659
Saliha Sağnıç, Özer Birge, Mehmet Sait Bakır, Ceyda Karadag, Tayup Şimşek
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引用次数: 1

摘要

目的:探讨影响9例宫颈神经内分泌癌复发及生存的临床病理特点。方法:回顾性分析2004年至2021年在Akdeniz大学妇科肿瘤门诊就诊的453例宫颈癌患者中发现的9例宫颈神经内分泌癌。Kaplan-Meier生存分析用于无进展生存期(PFS)和总生存期(OS)。使用均值、标准差、中位数、最小最大值和频率等数学函数进行描述性统计。分类数据以数字和百分比(%)表示。结果:453例宫颈癌患者中,神经内分泌组织学亚型患者9例(1.98%)。患者的平均总生存时间为26个月。5年生存率为53.3%,PFS为62.5%。最常见的亚型是小细胞神经内分泌癌。肿瘤大多在诊断时局部进展。3例为1b2期,4例为2b期,1例为3c2r期,1例为4b期。所有肿瘤均显示神经内分泌癌的免疫组化染色特征。本组患者的主要治疗方式为手术+辅助CRT。使用最多的化疗药物是顺铂/卡铂和依托泊苷。复发3例,死亡5例。结论:宫颈神经内分泌肿瘤是一种少见的肿瘤亚型,预后较差。不幸的是,由于基于手术、化疗和放疗的治疗方案的比较研究数量有限,目前还没有一个标准的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Clinicopathological Analysis of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review of 9 Cases.

Clinicopathological Analysis of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review of 9 Cases.

Clinicopathological Analysis of Neuroendocrine Carcinoma of the Uterine Cervix: A Single-Institution Retrospective Review of 9 Cases.

Aim: To evaluate the clinicopathological features affecting the recurrence and survival of 9 cases of neuroendocrine cancer of the cervix.

Method: We retrospectively analyzed 9 cervical neuroendocrine cancer cases identified among 453 cervical cancer patients between 2004 and 2021 at Akdeniz University Gynecological Oncology Outpatient Clinic. Kaplan-Meier survival analysis was used for progression-free survival (PFS) and overall survival (OS). Mathematical functions of mean, standard deviation, median, Min-Max values, and frequencies were used for descriptive statistics. The categorical data were expressed in numbers and percentages (%).

Results: Nine patients with neuroendocrine histological subtype were selected out of 453 patients diagnosed with cervical cancer (1.98%). The average overall survival time of the patients was 26 months. The 5-year survival rate was 53.3%, while the PFS was 62.5%. The most common subtype was small cell neuroendocrine cancer. Tumours were mostly locally advanced at the time of diagnosis. 3 patients' stage was 1b2, while 4 patients were 2b, 1 patient was 3c2r, and 1 patient was 4b. All tumours showed the immunohistochemical staining properties of neuroendocrine cancer. The main treatment modality applied to our patients was surgery + adjuvant CRT. The most used chemotherapeutic agents were cisplatin/carboplatin and etoposide. Recurrence was found in 3 cases, including 5 deaths.

Conclusion: Neuroendocrine tumour of the cervix is a rare subtype with a poor prognosis. Unfortunately, there is not yet a standard treatment protocol due to the limited number of comparative studies of surgery, chemotherapy, and radiotherapy based treatment schemes.

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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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