未确诊的隐球菌性脑膜脑炎伴大面积缺氧缺血性脑损伤,模拟3级弥漫性轴索损伤。

Q4 Medicine
Ceskoslovenska patologie Pub Date : 2021-01-01
Daniel Farkaš, Anna Kružlíková, Jana Němcová, Vladimír Hrabovský, Silvia Farkašová Iannaccone, Alžbeta Ginelliová, Lucia Fröhlichová, Marián Švajdler
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引用次数: 0

摘要

在这篇文章中,我们报告了一名50岁免疫功能正常的女性的尸检结果,她因意识状态改变而住院。住院期间进行的检查,包括脑脊液分析,未能确定导致渐进性意识丧失和四肢瘫痪的感染因子。患者在入院后8天内死亡。死后显微镜和培养检查显示隐球菌属。死亡原因是隐球菌性脑膜脑炎。组织学检查显示在苏木精和伊红染色的脑切片中有模拟红细胞的隐球菌积聚和大量出血。血管床多灶性闭塞伴缺氧缺血性脑损伤,类似外伤性弥漫性轴索损伤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Undiagnosed cryptococcal meningoencephalitis with extensive hypoxic-ischemic brain injury mimicking grade 3 diffuse axonal injury.

In this article, we report the autopsy findings of a 50-year-old immunocompetent woman, who was hospitalized with an altered state of consciousness. Examinations, including cerebrospinal fluid analysis, carried out during hospitalization failed to identify the infectious agent causing progressive loss of consciousness and quadriparesis. The patient died within 8 days of admission to the hospital. Post-mortem microscopic and culture examination revealed Cryptococcus species. Death was attributed to cryptococcal meningoencephalitis. Histologic examination revealed accumulation of cryptococcus mimicking erythrocytes and extensive hemorrhage in hematoxylin and eosin-stained sections of the brain. Multifocal obliteration of the vascular bed by yeast was accompanied by hypoxic-ischemic brain injury mimicking traumatic diffuse axonal injury.

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来源期刊
Ceskoslovenska patologie
Ceskoslovenska patologie Medicine-Medicine (all)
CiteScore
0.40
自引率
0.00%
发文量
17
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