结膜上皮内瘤变(CIN)局部干扰素治疗后急性前葡萄膜炎。

GMS ophthalmology cases Pub Date : 2021-07-20 eCollection Date: 2021-01-01 DOI:10.3205/oc000184
Ameay V Naravane, Jacquelyn Weber, Grishma Barucha, Joshua H Hou
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引用次数: 2

摘要

目的:眼表鳞状瘤变(OSSN)是最常见的非黑素细胞性眼表肿瘤。结膜上皮内瘤变(CIN)是一种OSSN类型,可以通过外用干扰素α-2b (IFN α-2b)、5-氟尿嘧啶(5-FU)或丝裂霉素c进行医学治疗。虽然在HIV人群中有对IFN α-2b的矛盾反应的报道,但我们报告了一个在免疫能力强的个体中出现矛盾反应的病例。方法:一名65岁免疫功能正常的女性以CIN就诊。结果:她开始局部使用IFN α-2b,导致意想不到的低剂量,角膜上皮缺损增加,病变大小增加。切换到局部5-FU导致CIN病变大小减小和上皮缺损的消退。结论:局部使用IFN α-2b可在某些患者中引起CIN病变的矛盾恶化。提供者应该意识到这种反应,以及出现的体征和症状,在治疗CIN时做出适当的治疗改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN).

Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN).

Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN).

Acute anterior uveitis after topical interferon for conjunctival intraepithelial neoplasia (CIN).

Objective: Ocular surface squamous neoplasia (OSSN) is the most common type of non-melanocytic ocular surface tumor. Conjunctival intraepithelial neoplasia (CIN) is a type of OSSN that be medically managed by either topical interferon alpha-2b (IFN α-2b), 5-fluorouracil (5-FU), or mitomycin C. While a paradoxical response to IFN α-2b in the HIV population has been reported, we report a case of a paradoxical response in an immunocompetent individual. Methods: A 65-year-old immunocompetent female presents to the clinic with CIN. Results: She is started on topical IFN α-2b, resulting in an unexpected hypopyon, increased corneal epithelial defect, and increased size of the lesion. Switching to topical 5-FU resulted in decreasing size of the CIN lesion and resolution of the epithelial defect. Conclusions: Topical IFN α-2b can produce a paradoxical worsening of CIN lesions in some patients. Providers should be aware of this reaction, as well as the presenting signs and symptoms, to make appropriate treatment changes when treating CIN.

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