减肥手术后一种新的免疫相关基因特征在组织学上与非酒精性脂肪肝相关。

IF 3.5 4区 生物学 Q2 ENDOCRINOLOGY & METABOLISM
Yancheng Song, Jan Zhang, Hexiang Wang, Dong Guo, Chentong Yuan, Bo Liu, Hao Zhong, Dongmei Li, Yu Li
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引用次数: 9

摘要

越来越多的证据表明免疫相关基因(IRGs)在减肥手术(BS)中起着重要作用。通过分析GEO的两个表达谱(GSE59034和GSE29409),我们确定了BS后脂肪组织的差异表达免疫相关基因(DEIRGs)。随后,通过富集分析、GSEA和PPI网络来确定中枢IRGs和相关通路。用受试者工作特征(ROC)曲线下面积(AUC)评价信号的有效性。采用CIBERSORT算法评价浸润免疫细胞的相对丰度在GSE59034和GSE29409数据集之间发现DEIRGs。GSE58979和GSE48452的AUC分别为0.904和0.865。有趣的是,该特征在诊断非酒精性脂肪性肝病(NAFLD)方面也表现出良好的性能(AUC分别为0.834和0.800)。活化的中性粒细胞、巨噬细胞M2、巨噬细胞M0和树突状细胞数量明显减少。BS后脂肪组织中调节性T细胞、单核细胞、静止肥大细胞和浆细胞的浸润增加。新提出的IRGs特征揭示了BS的潜在免疫机制,是区分NAFLD严重程度的有希望的生物标志物。这将为肥胖和NAFLD的治疗策略提供新的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.

A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.

A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.

A novel immune-related genes signature after bariatric surgery is histologically associated with non-alcoholic fatty liver disease.

Increasing evidence shows that immune-related genes (IRGs) play an important role in bariatric surgery (BS). We identified differentially expressed immune-related genes (DEIRGs) of adipose tissue after BS by analysing the two expression profiles of GEO (GSE59034 and GSE29409). Subsequently, enrichment analysis, GSEA and PPI networks were examined to identify the hub IRGs and related pathways. The performance of the signature was evaluated by area under the curve (AUC) of the receiver operating characteristic (ROC). CIBERSORT algorithm was used to evaluate the relative abundance of infiltrated immune cells.42 DEIRGs were found between the GSE59034 and GSE29409 datasets. The AUC of the signature was 0.904 and 0.865 in the GSE58979 and GSE48452, respectively. Interestingly, the signature also showed good performance in diagnosing non-alcoholic fatty liver disease (NAFLD) (AUC was 0.834 and 0.800, respectively). The number of neutrophils, macrophages M2, macrophages M0 and dendritic cells activated decreased significantly. After BS, the infiltration of T cells regulatory, monocytes, mast cells resting and plasma cells in adipose tissue increased. The novel proposed IRGs signature reveals the underlying immune mechanism of BS and is a promising biomarker for distinguishing the severity of NAFLD. This will provide new insights into strategies for treating obesity and NAFLD.

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来源期刊
Adipocyte
Adipocyte Medicine-Histology
CiteScore
6.50
自引率
3.00%
发文量
46
审稿时长
32 weeks
期刊介绍: Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.
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