比较氙气和七氟醚麻醉对术后神经损伤生物标志物的影响:一项随机对照试验。

IF 3 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Steven McGuigan, Lisbeth Evered, David A Scott, Brendan Silbert, Henrik Zetterberg, Kaj Blennow
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引用次数: 4

摘要

全身麻醉和手术与神经损伤生物标志物的增加有关。围手术期这些神经损伤生物标志物的升高与术后谵妄有关。在动物模型中,氙已被证明对一系列神经损伤有保护作用。氙气麻醉在围手术期是否具有神经保护作用还有待观察。24名计划进行碎石的参与者随机接受氙气或七氟醚全身麻醉。氙气组与七氟醚组术后神经损伤生物标志物浓度差异无统计学意义。在诱导后1小时,所有三种生物标志物的浓度从基线显著增加,并在诱导后5小时恢复到基线。全麻碎石与诱导后1小时神经损伤生物标志物总tau、神经丝光和苏氨酸181磷酸化的tau (tau磷酸化的标志)显著增加相关。本议定书经墨尔本圣文森特医院伦理委员会批准(批准号:HREC/18/SVHM/221)于2018年7月20日发布,并已在澳大利亚新西兰临床试验注册中心注册(注册号:ACTRN12618000916246)于2018年5月31日发布。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.

Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.

Comparing the effect of xenon and sevoflurane anesthesia on postoperative neural injury biomarkers: a randomized controlled trial.

General anesthesia and surgery are associated with an increase in neural injury biomarkers. Elevations of these neural injury biomarkers in the perioperative period are associated with postoperative delirium. Xenon has been shown to be protective against a range of neurological insults in animal models. It remains to be seen if xenon anesthesia is neuroprotective in the perioperative setting in humans. Twenty-four participants scheduled for lithotripsy were randomized to receive either xenon or sevoflurane general anesthesia. There was no statistically significant difference in the concentrations of postoperative neural injury biomarkers between the xenon and sevoflurane group. Following the procedure there was a significant increase in the concentration from baseline of all three biomarkers at 1 hour post-induction with a return to baseline at 5 hours. General anesthesia for lithotripsy was associated with a significant increase at 1 hour post-induction in the neural injury biomarkers total tau, neurofilament light and tau phosphorylated at threonine 181, a marker of tau phosphorylation. The protocol was approved by the St. Vincent's Hospital Melbourne Ethics Committee (approval No. HREC/18/SVHM/221) on July 20, 2018 and was registered with the Australia New Zealand Clinical Trials Registry (registration No. ACTRN12618000916246) on May 31, 2018.

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来源期刊
Medical Gas Research
Medical Gas Research MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
5.10
自引率
13.80%
发文量
35
期刊介绍: Medical Gas Research is an open access journal which publishes basic, translational, and clinical research focusing on the neurobiology as well as multidisciplinary aspects of medical gas research and their applications to related disorders. The journal covers all areas of medical gas research, but also has several special sections. Authors can submit directly to these sections, whose peer-review process is overseen by our distinguished Section Editors: Inert gases - Edited by Xuejun Sun and Mark Coburn, Gasotransmitters - Edited by Atsunori Nakao and John Calvert, Oxygen and diving medicine - Edited by Daniel Rossignol and Ke Jian Liu, Anesthetic gases - Edited by Richard Applegate and Zhongcong Xie, Medical gas in other fields of biology - Edited by John Zhang. Medical gas is a large family including oxygen, hydrogen, carbon monoxide, carbon dioxide, nitrogen, xenon, hydrogen sulfide, nitrous oxide, carbon disulfide, argon, helium and other noble gases. These medical gases are used in multiple fields of clinical practice and basic science research including anesthesiology, hyperbaric oxygen medicine, diving medicine, internal medicine, emergency medicine, surgery, and many basic sciences disciplines such as physiology, pharmacology, biochemistry, microbiology and neurosciences. Due to the unique nature of medical gas practice, Medical Gas Research will serve as an information platform for educational and technological advances in the field of medical gas.
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