{"title":"找到火花。","authors":"Joel M Kralj","doi":"10.1089/bioe.2021.0017","DOIUrl":null,"url":null,"abstract":"<p><p>It began, as with many good things, at a happy hour. Adam Cohen, a young assistant professor asked whether rhodopsins could be used to optically sense voltage. In the heady days of 2009, channel rhodopsin had just been unveiled as a voltage actuator in neurons. Adam had the insight to question whether rhodopsins could be run in reverse; could optical changes in a protein relay the cellular voltage state using light? This was one of the earliest lessons I learned under his mentorship, and the first piece of advice in this retrospective-turning a scientific question or statement on its head can be the basis for many fantastic research projects.</p>","PeriodicalId":29923,"journal":{"name":"Bioelectricity","volume":"3 2","pages":"143-146"},"PeriodicalIF":1.6000,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370483/pdf/bioe.2021.0017.pdf","citationCount":"0","resultStr":"{\"title\":\"Finding the Spark.\",\"authors\":\"Joel M Kralj\",\"doi\":\"10.1089/bioe.2021.0017\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>It began, as with many good things, at a happy hour. Adam Cohen, a young assistant professor asked whether rhodopsins could be used to optically sense voltage. In the heady days of 2009, channel rhodopsin had just been unveiled as a voltage actuator in neurons. Adam had the insight to question whether rhodopsins could be run in reverse; could optical changes in a protein relay the cellular voltage state using light? This was one of the earliest lessons I learned under his mentorship, and the first piece of advice in this retrospective-turning a scientific question or statement on its head can be the basis for many fantastic research projects.</p>\",\"PeriodicalId\":29923,\"journal\":{\"name\":\"Bioelectricity\",\"volume\":\"3 2\",\"pages\":\"143-146\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2021-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370483/pdf/bioe.2021.0017.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bioelectricity\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1089/bioe.2021.0017\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/6/16 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bioelectricity","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1089/bioe.2021.0017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/6/16 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
It began, as with many good things, at a happy hour. Adam Cohen, a young assistant professor asked whether rhodopsins could be used to optically sense voltage. In the heady days of 2009, channel rhodopsin had just been unveiled as a voltage actuator in neurons. Adam had the insight to question whether rhodopsins could be run in reverse; could optical changes in a protein relay the cellular voltage state using light? This was one of the earliest lessons I learned under his mentorship, and the first piece of advice in this retrospective-turning a scientific question or statement on its head can be the basis for many fantastic research projects.
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