Pilar E Núñez Ortega, María E Meneses, Iván Delgado-Enciso, César Antonio Irecta-Nájera, Itandehui Castro-Quezada, Roberto Solís-Hernández, Elena Flores-Guillén, Rosario García-Miranda, Adán Valladares-Salgado, Daniel Locia-Morales, Héctor Ochoa-Díaz-López
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引用次数: 1
摘要
背景:代谢综合征(MetS)是一组复杂的危险因素，被认为是一个多基因和多因素的实体。本研究的目的是确定恰帕斯玛雅社区成年女性rs9939609-FTO多态性与MetS成分的关系。方法:在一项横断面研究中，从墨西哥恰帕斯三个地区的291名成年妇女中获得了社会人口学、人体测量学、临床和生化数据。估计met的患病率、rs9939609-FTO的等位基因和基因型频率。使用多变量逻辑回归模型来评估单核苷酸多态性(SNP)与每个MetS成分的关联。结果:met的患病率为60%。在优势模型中，我们发现rs9939609-FTO与高血糖之间存在统计学意义上的关联(OR 2.6;95% ci 1.3-5.3;p = 0.007)。结论:恰帕斯玛雅社区的女性met患病率高，FTO变异与高血糖有相关关系。这是第一次在恰帕斯的玛雅土著社区进行的研究。
Association of rs9939609-FTO with metabolic syndrome components among women from Mayan communities of Chiapas, Mexico.
Background: Metabolic syndrome (MetS) is a complex cluster of risk factors, considered as a polygenic and multifactorial entity. The objective of this study was to determine the association of rs9939609-FTO polymorphism and MetS components in adult women of Mayan communities of Chiapas.
Methods: In a cross-sectional study, sociodemographic, anthropometric, clinical, and biochemical data were obtained from 291 adult women from three regions of Chiapas, Mexico. The prevalence of MetS and the allele and genotype frequencies of the rs9939609-FTO were estimated. Multivariate logistic regression models were used to assess the association of the single nucleotide polymorphism (SNP) with each of the MetS components.
Results: The MetS prevalence was 60%. We found a statistically significant association between rs9939609-FTO and hyperglycemia in the dominant model (OR 2.6; 95% CI 1.3-5.3; p = 0.007).
Conclusions: Women from Mayan communities of Chiapas presented a high prevalence of MetS and a relevant association of the FTO variant with hyperglycemia. This is the first study carried out in these Mayan indigenous communities from Chiapas.
期刊介绍：
Journal of Physiological Anthropology (JPA) is an open access, peer-reviewed journal that publishes research on the physiological functions of modern mankind, with an emphasis on the physical and bio-cultural effects on human adaptability to the current environment.
The objective of JPA is to evaluate physiological adaptations to modern living environments, and to publish research from different scientific fields concerned with environmental impact on human life.
Topic areas include, but are not limited to:
environmental physiology
bio-cultural environment
living environment
epigenetic adaptation
development and growth
age and sex differences
nutrition and morphology
physical fitness and health
Journal of Physiological Anthropology is the official journal of the Japan Society of Physiological Anthropology.
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