一种可控和通用的NCA聚合方法，用于合成多肽

IF 3.9 2区化学 Q2 POLYMER SCIENCE

Polymer Chemistry Pub Date : 2013-04-08 DOI:10.1039/C3PY00347G

Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz and María J. Vicent

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引用次数: 92

摘要

一个通用的和简单的方法来制备定义良好的聚谷氨酸纳米载体描述。具有非亲核四氟硼酸盐阴离子的铵盐首次被用作α- n-羧基氢化物(NCAs)开环聚合的引发剂，从而可以合成具有确定分子量(高达800个单位)、低多分散性(<1.2)、控制链端官能性、充分的立体选择性和没有任何有毒杂质痕迹的多谱尺度的谷氨酸，从而允许生物医学应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A controlled and versatile NCA polymerization method for the synthesis of polypeptides†‡

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A controlled and versatile NCA polymerization method for the synthesis of polypeptides†‡

A versatile and simple methodology for the preparation of well-defined polyglutamate nanocarriers is described. For the first time ammonium salts with non-nucleophilic tetrafluoroborate anions are used as initiators for the ring opening polymerization of α-N-carboxyanhydrides (NCAs) allowing a multigram scale polyglutamate synthesis with defined molecular weight (up to 800 units), low polydispersity (<1.2), controlled chain end functionality and adequate stereoselectivity and absence of any trace of toxic impurity to allow biomedical applications.

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来源期刊

Polymer Chemistry POLYMER SCIENCE-

CiteScore

8.60

自引率

8.70%

发文量

535

审稿时长

1.7 months

期刊介绍： Polymer Chemistry welcomes submissions in all areas of polymer science that have a strong focus on macromolecular chemistry. Manuscripts may cover a broad range of fields, yet no direct application focus is required.