生物膜基纳米材料在癌症治疗中的最新进展

IF 5.8 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS
Mengling Shen, Xiaojie Wu, Minqian Zhu and Xuan Yi
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引用次数: 4

摘要

纳米材料因其在肿瘤中的渗透性和滞留性增强以及多功能整合能力,在肿瘤治疗中显示出显著的优势。从各种细胞及其分泌的膜结构中收集的生物膜,可以进一步应用于建立具有完美生物相容性、肿瘤靶向能力、免疫刺激活性和可调节通用性的膜基纳米材料,用于癌症治疗。本文根据膜的来源,将膜分为四大类:(1)细胞膜;(2)分泌膜;(3)工程膜;(4)杂化膜。首先,可以从人体的自然细胞、肿瘤组织细胞和细菌中提取细胞膜。分泌膜主要是指外泌体、凋亡小体和细菌外膜囊泡,从工程细胞中获得具有特异性蛋白/肽表达或治疗性包涵体的膜。最后,混合膜将由上述两个或多个膜组成。这些膜可以自身形成载药纳米颗粒或包裹多功能纳米颗粒,进一步实现高效的癌症治疗。我们总结了各种生物膜基纳米材料在癌症治疗中的应用,指出了它们的优势和需要进一步改进的地方,为这一领域提供了系统的知识和进一步优化的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent advances in biological membrane-based nanomaterials for cancer therapy

Recent advances in biological membrane-based nanomaterials for cancer therapy

Nanomaterials have shown significant advantages in cancer theranostics, owing to their enhanced permeability and retention effect in tumors and multi-function integration capability. Biological membranes, which are collected from various cells and their secreted membrane structures, can further be applied to establish membrane-based nanomaterials with perfect biocompatibility, tumor-targeting capacity, immune-stimulatory activity and adjustable versatility for cancer therapy. In this review, according to their source, membranes are divided into four groups: (1) cell membranes; (2) secretory membranes; (3) engineered membranes; and (4) hybrid membranes. First, cell membranes can be extracted from natural cells of the body, tumor tissue cells, and bacteria. Furthermore, secretory membranes mainly refer to exosome, apoptotic body and bacterial outer membrane vesicle, and membranes with specific protein/peptide expression or therapeutic inclusions are obtained from engineered cells. Finally, a hybrid membrane will be constituted by two or more of the abovementioned membranes. These membranes can form drug-carrying nanoparticles themselves or coat multi-functional nanoparticles, further realizing efficient cancer therapy. We summarize the application of various biological membrane-based nanomaterials in cancer therapy and point out their advantages as well as the places that need to be further improved, providing systematic knowledge of this field and a strategy for further optimization.

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来源期刊
Biomaterials Science
Biomaterials Science MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.50%
发文量
556
期刊介绍: Biomaterials Science is an international high impact journal exploring the science of biomaterials and their translation towards clinical use. Its scope encompasses new concepts in biomaterials design, studies into the interaction of biomaterials with the body, and the use of materials to answer fundamental biological questions.
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