在不久的将来，全基因组测序会成为男性不育症的一线遗传分析吗?

IF 2.4 3区医学 Q2 ANDROLOGY

Basic and Clinical Andrology Pub Date : 2021-08-19 DOI:10.1186/s12610-021-00138-4

Farah Ghieh, Anne-Laure Barbotin, Clara Leroy, François Marcelli, Nelly Swierkowsky-Blanchard, Valérie Serazin, Béatrice Mandon-Pepin, François Vialard

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引用次数: 9

摘要

虽然男性不育的遗传分析最初是基于候选基因方法，但下一代测序技术(如全外显子组测序(WES))的发展提供了在单一程序中分析许多基因的机会。为了在遗传咨询后推荐WES或全基因组测序(WGS)，需要对当前男性不育症的遗传筛查策略进行客观评估，即使目前我们必须考虑到这种程序的复杂性，这在本评论中没有讨论。

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Will whole-genome sequencing become the first-line genetic analysis for male infertility in the near future?

Whereas the initially strategy for the genetic analysis of male infertility was based on a candidate gene approach, the development of next-generation sequencing technologies (such as whole-exome sequencing (WES)) provides an opportunity to analyze many genes in a single procedure. In order to recommend WES or whole-genome sequencing (WGS) after genetic counselling, an objective evaluation of the current genetic screening strategy for male infertility is required, even if, at present, we have to take into consideration the complexity of such a procedure, not discussed in this commentary.

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来源期刊

Basic and Clinical Andrology Medicine-Urology

CiteScore

3.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： Basic and Clinical Andrology is an open access journal in the domain of andrology covering all aspects of male reproductive and sexual health in both human and animal models. The journal aims to bring to light the various clinical advancements and research developments in andrology from the international community.