恶性疟原虫锌指蛋白

IF 2.6 2区生物学 Q3 CELL BIOLOGY

Cellular Microbiology Pub Date : 2021-08-21 DOI:10.1111/cmi.13387

Che Julius Ngwa, Afia Farrukh, Gabriele Pradel

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引用次数: 18

摘要

锌指蛋白(ZFPs)是一个具有一个或多个锌指结构域的蛋白大家族，锌在稳定结构域中起重要作用。ZFPs可以与DNA, RNA，脂质甚至其他蛋白质相互作用，因此有助于多种细胞过程，包括转录调节，泛素介导的蛋白质降解，mRNA衰变和稳定性。本文首次对恶性疟原虫的ZFPs进行了全面的分类，并对疟原虫的主要ZFPs包括C2H2、CCCH、RING finger和PHD finger蛋白进行了初步的认识。恶性疟原虫基因组编码170个锌指蛋白(ZFPs)。ZFPs以C2H2、CCCH、RING finger和PHD finger亚族最为典型。已知的ZFP功能包括调控mRNA代谢和蛋白质平衡。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Zinc finger proteins of Plasmodium falciparum

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Zinc finger proteins of Plasmodium falciparum

Zinc finger proteins (ZFPs) are a large diverse family of proteins with one or more zinc finger domains in which zinc is important in stabilising the domain. ZFPs can interact with DNA, RNA, lipids or even other proteins and therefore contribute to diverse cellular processes including transcriptional regulation, ubiquitin-mediated protein degradation, mRNA decay and stability. In this review, we provide the first comprehensive classification of ZFPs of the malaria parasite Plasmodium falciparum and provide a state of knowledge on the main ZFPs in the parasite, which include the C2H2, CCCH, RING finger and the PHD finger proteins.

Take aways

The Plasmodium falciparum genome encodes 170 putative Zinc finger proteins (ZFPs).
The C2H2, CCCH, RING finger and PHD finger subfamilies of ZFPs are most represented.
Known ZFP functions include the regulation of mRNA metabolism and proteostasis.

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来源期刊

Cellular Microbiology 生物-微生物学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.