{"title":"金合欢对代谢性疾病的药理作用：肠道级生物活性和肠道微生物群的有利调节。","authors":"Manas Ranjan Saha, Priyankar Dey","doi":"10.1080/13813455.2021.1966475","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Obesity-associated chronic metabolic disease is a leading contributor to mortality globally. Plants belonging to the genera <i>Acacia</i> are routinely used for the treatment of diverse metabolic diseases under different ethnomedicinal practices around the globe.</p><p><strong>Objective: </strong>The current review centres around the pharmacological evidence of intestinal-level mechanisms for metabolic health benefits by <i>Acacia</i> spp.</p><p><strong>Results: </strong><i>Acacia</i> spp. increase the proportions of gut commensals (<i>Bifidobacterium</i> and <i>Lactobacillus</i>) and reduces the population of opportunistic pathobionts (<i>Escherichia coli</i> and <i>Clostridium</i>). <i>Acacia</i> gum that is rich in fibre, can also be a source of prebiotics to improve gut health. The intestinal-level anti-inflammatory activities of <i>Acacia</i> are likely to contribute to improvements in gut barrier function that would prevent gut-to-systemic endotoxin translocation and limit \"low-grade\" inflammation associated with metabolic diseases.</p><p><strong>Conclusion: </strong>This comprehensive review for the first time has emphasised the intestinal-level benefits of <i>Acacia</i> spp. which could be instrumental in limiting the burden of metabolic disease.</p>","PeriodicalId":8331,"journal":{"name":"Archives of Physiology and Biochemistry","volume":" ","pages":"70-86"},"PeriodicalIF":2.5000,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pharmacological benefits of <i>Acacia</i> against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota.\",\"authors\":\"Manas Ranjan Saha, Priyankar Dey\",\"doi\":\"10.1080/13813455.2021.1966475\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Obesity-associated chronic metabolic disease is a leading contributor to mortality globally. Plants belonging to the genera <i>Acacia</i> are routinely used for the treatment of diverse metabolic diseases under different ethnomedicinal practices around the globe.</p><p><strong>Objective: </strong>The current review centres around the pharmacological evidence of intestinal-level mechanisms for metabolic health benefits by <i>Acacia</i> spp.</p><p><strong>Results: </strong><i>Acacia</i> spp. increase the proportions of gut commensals (<i>Bifidobacterium</i> and <i>Lactobacillus</i>) and reduces the population of opportunistic pathobionts (<i>Escherichia coli</i> and <i>Clostridium</i>). <i>Acacia</i> gum that is rich in fibre, can also be a source of prebiotics to improve gut health. The intestinal-level anti-inflammatory activities of <i>Acacia</i> are likely to contribute to improvements in gut barrier function that would prevent gut-to-systemic endotoxin translocation and limit \\\"low-grade\\\" inflammation associated with metabolic diseases.</p><p><strong>Conclusion: </strong>This comprehensive review for the first time has emphasised the intestinal-level benefits of <i>Acacia</i> spp. which could be instrumental in limiting the burden of metabolic disease.</p>\",\"PeriodicalId\":8331,\"journal\":{\"name\":\"Archives of Physiology and Biochemistry\",\"volume\":\" \",\"pages\":\"70-86\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archives of Physiology and Biochemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/13813455.2021.1966475\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/8/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Physiology and Biochemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/13813455.2021.1966475","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/8/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Pharmacological benefits of Acacia against metabolic diseases: intestinal-level bioactivities and favorable modulation of gut microbiota.
Context: Obesity-associated chronic metabolic disease is a leading contributor to mortality globally. Plants belonging to the genera Acacia are routinely used for the treatment of diverse metabolic diseases under different ethnomedicinal practices around the globe.
Objective: The current review centres around the pharmacological evidence of intestinal-level mechanisms for metabolic health benefits by Acacia spp.
Results: Acacia spp. increase the proportions of gut commensals (Bifidobacterium and Lactobacillus) and reduces the population of opportunistic pathobionts (Escherichia coli and Clostridium). Acacia gum that is rich in fibre, can also be a source of prebiotics to improve gut health. The intestinal-level anti-inflammatory activities of Acacia are likely to contribute to improvements in gut barrier function that would prevent gut-to-systemic endotoxin translocation and limit "low-grade" inflammation associated with metabolic diseases.
Conclusion: This comprehensive review for the first time has emphasised the intestinal-level benefits of Acacia spp. which could be instrumental in limiting the burden of metabolic disease.
期刊介绍：
Archives of Physiology and Biochemistry: The Journal of Metabolic Diseases is an international peer-reviewed journal which has been relaunched to meet the increasing demand for integrated publication on molecular, biochemical and cellular aspects of metabolic diseases, as well as clinical and therapeutic strategies for their treatment. It publishes full-length original articles, rapid papers, reviews and mini-reviews on selected topics. It is the overall goal of the journal to disseminate novel approaches to an improved understanding of major metabolic disorders.
The scope encompasses all topics related to the molecular and cellular pathophysiology of metabolic diseases like obesity, type 2 diabetes and the metabolic syndrome, and their associated complications.
Clinical studies are considered as an integral part of the Journal and should be related to one of the following topics:
-Dysregulation of hormone receptors and signal transduction
-Contribution of gene variants and gene regulatory processes
-Impairment of intermediary metabolism at the cellular level
-Secretion and metabolism of peptides and other factors that mediate cellular crosstalk
-Therapeutic strategies for managing metabolic diseases
Special issues dedicated to topics in the field will be published regularly.
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