在津巴布韦资源有限的环境中对高效液相色谱法奈韦拉平血浆测定法进行交叉验证。

IF 1 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

African Journal of Laboratory Medicine Pub Date : 2021-07-08 eCollection Date: 2021-01-01 DOI:10.4102/ajlm.v10i1.1264

Faithful Makita-Chingombe, Anthony T Podany, Timothy Mykris, Farai Muzambi, Richard W Browne, Andrew J Ocque, Robin DiFrancesco, Lee C Winchester, Courtney V Fletcher, Tinashe Mudzviti, Charles C Maponga, Gene D Morse

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引用次数: 0

摘要

津巴布韦大学建立了一个国际艾滋病药理学专业实验室（PSL），以提高生物分析和研究人员的能力。内布拉斯加大学医学中心的 PSL 与津巴布韦大学的 PSL 对艾滋病临床试验小组 5279 方案样本中血浆奈韦拉平的定量进行了比较。两家 PSL 均采用了内部开发的方法，即反相高效液相色谱法和紫外检测法。87%的交叉验证结果显示出 ± 20% 的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe.

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Cross-validation of a high-performance liquid chromatography nevirapine plasma assay in a resource-limited setting in Zimbabwe.

An international HIV pharmacology specialty laboratory (PSL) was established at the University of Zimbabwe to increase bioanalytical and investigator capacities. Quantitation of plasma nevirapine in samples from the AIDS Clinical Trials Group protocol 5279 was compared between the University of Nebraska Medical Center PSL and the University of Zimbabwe PSL. Both PSLs employed internally developed methods utilising reverse-phase high-performance liquid chromatography with ultraviolet detection. Eighty-seven percent of the cross-validation results exhibited ± 20% difference.

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来源期刊

African Journal of Laboratory Medicine MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

12 weeks

期刊介绍： The African Journal of Laboratory Medicine, the official journal of ASLM, focuses on the role of the laboratory and its professionals in the clinical and public healthcare sectors,and is specifically based on an African frame of reference. Emphasis is on all aspects that promote and contribute to the laboratory medicine practices of Africa. This includes, amongst others: laboratories, biomedical scientists and clinicians, medical community, public health officials and policy makers, laboratory systems and policies (translation of laboratory knowledge, practices and technologies in clinical care), interfaces of laboratory with medical science, laboratory-based epidemiology, laboratory investigations, evidence-based effectiveness in real world (actual) settings.