George Uchenna Eleje, Godwin Otuodichinma Akaba, Ikechukwu Innocent Mbachu, Ayyuba Rabiu, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Preye Owen Fiebai, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chinyere Ukamaka Onubogu, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Uchenna Chukwunonso Ogwaluonye, Sussan Ifeyinwa Nweje, Richard Obinwanne Egeonu, Odion Emmanuel Igue, Chiamaka Henrietta Jibuaku, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Aisha Ismaila Numan, Ogbonna Dennis Okoro, Solace Amechi Omoruyi, Ijeoma Chioma Oppah, Ubong Inyang Anyang, Aishat Ahmed, Osita Samuel Umeononihu, Eric Okechukwu Umeh, Ekene Agatha Emeka, Arinze Anthony Onwuegbuna, Emeka Philip Igbodike, Ifeoma Clara Ajuba, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu
{"title":"尼日利亚孕妇乙肝疫苗接种覆盖率：全国试点横断面研究。","authors":"George Uchenna Eleje, Godwin Otuodichinma Akaba, Ikechukwu Innocent Mbachu, Ayyuba Rabiu, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Preye Owen Fiebai, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chinyere Ukamaka Onubogu, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Uchenna Chukwunonso Ogwaluonye, Sussan Ifeyinwa Nweje, Richard Obinwanne Egeonu, Odion Emmanuel Igue, Chiamaka Henrietta Jibuaku, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Aisha Ismaila Numan, Ogbonna Dennis Okoro, Solace Amechi Omoruyi, Ijeoma Chioma Oppah, Ubong Inyang Anyang, Aishat Ahmed, Osita Samuel Umeononihu, Eric Okechukwu Umeh, Ekene Agatha Emeka, Arinze Anthony Onwuegbuna, Emeka Philip Igbodike, Ifeoma Clara Ajuba, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu","doi":"10.1177/25151355211032595","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women.</p><p><strong>Methods: </strong>This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when <i>p</i>-value was < 0.05.</p><p><strong>Results: </strong>Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9-18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08-1.01, <i>p</i> = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants' level of education (aOR 3.09; 95% CI 0.95-10.16; <i>p</i> = 0.061) did not remain significant.</p><p><strong>Conclusions: </strong>In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake.</p><p><strong>Funding: </strong>TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":"9 ","pages":"25151355211032595"},"PeriodicalIF":0.0000,"publicationDate":"2021-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/a3/10.1177_25151355211032595.PMC8327013.pdf","citationCount":"0","resultStr":"{\"title\":\"Pregnant women's hepatitis B vaccination coverage in Nigeria: a national pilot cross-sectional study.\",\"authors\":\"George Uchenna Eleje, Godwin Otuodichinma Akaba, Ikechukwu Innocent Mbachu, Ayyuba Rabiu, Olabisi Morebise Loto, Hadiza Abdullahi Usman, Preye Owen Fiebai, Rebecca Chinyelu Chukwuanukwu, Ngozi Nneka Joe-Ikechebelu, Chike Henry Nwankwo, Stephen Okoroafor Kalu, Chinyere Ukamaka Onubogu, Chukwuanugo Nkemakonam Ogbuagu, Shirley Nneka Chukwurah, Chinwe Elizabeth Uzochukwu, Samuel Oluwagbenga Inuyomi, Bukola Abimbola Adesoji, Uchenna Chukwunonso Ogwaluonye, Sussan Ifeyinwa Nweje, Richard Obinwanne Egeonu, Odion Emmanuel Igue, Chiamaka Henrietta Jibuaku, Prince Ogbonnia Aja, Chiamaka Perpetua Chidozie, Hadiza Sani Ibrahim, Fatima Ele Aliyu, Aisha Ismaila Numan, Ogbonna Dennis Okoro, Solace Amechi Omoruyi, Ijeoma Chioma Oppah, Ubong Inyang Anyang, Aishat Ahmed, Osita Samuel Umeononihu, Eric Okechukwu Umeh, Ekene Agatha Emeka, Arinze Anthony Onwuegbuna, Emeka Philip Igbodike, Ifeoma Clara Ajuba, Ibrahim Adamu Yakasai, Oliver Chukwujekwu Ezechi, Joseph Ifeanyichukwu Ikechebelu\",\"doi\":\"10.1177/25151355211032595\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women.</p><p><strong>Methods: </strong>This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when <i>p</i>-value was < 0.05.</p><p><strong>Results: </strong>Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9-18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08-1.01, <i>p</i> = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants' level of education (aOR 3.09; 95% CI 0.95-10.16; <i>p</i> = 0.061) did not remain significant.</p><p><strong>Conclusions: </strong>In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake.</p><p><strong>Funding: </strong>TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).</p>\",\"PeriodicalId\":33285,\"journal\":{\"name\":\"Therapeutic Advances in Vaccines and Immunotherapy\",\"volume\":\"9 \",\"pages\":\"25151355211032595\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-07-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/97/a3/10.1177_25151355211032595.PMC8327013.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Vaccines and Immunotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/25151355211032595\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2021/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Vaccines and Immunotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/25151355211032595","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2021/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
摘要
目的确定孕妇的乙肝疫苗接种率、全剂量（⩾3）接种率以及影响接种率的相关因素：这是一项横断面研究，研究对象是在尼日利亚所有地缘政治区的六家三级医院接受产前护理的孕妇。同意参与研究的孕妇填写了有关乙肝疫苗接种情况和覆盖率的筛查问题。主要结果指标为乙肝疫苗接种覆盖率、剂量以及影响接种率的因素。通过卡方检验进行二元分析，并使用条件逻辑回归分析来确定与接种率相关的变量。计算了几率比（ORs）和调整几率比（aORs），当 P 值为 "结果 "时，统计学意义成立：在完成访谈问题的 159 名孕妇中，21 人[13.2%，95% 置信区间 (CI) 7.9-18.5%]接种了一至三剂乙肝疫苗。接种剂量分别为：三剂（8/159，5.0%）、两剂（5/159，3.1%）和一剂（8/159，5.0%）。未接种疫苗的原因包括：对疫苗缺乏了解 83/138（60.1%），无法获得疫苗 11/138（8.0%），乙肝病毒阳性 10/138（7.2%）。受教育程度对乙肝疫苗接种率有显著影响（OR 0.284，95% CI 0.08-1.01，p = 0.041），但在对混杂因素进行调整的多变量逻辑回归中，乙肝疫苗接种率与参与者受教育程度之间的关系（aOR 3.09；95% CI 0.95-10.16；p = 0.061）并不显著：结论：在尼日利亚，全国孕妇乙肝疫苗接种率似乎很低，全剂量接种率甚至更低。教育水平与乙肝疫苗接种率没有正相关，而缺乏对疫苗的认识是不接种的最常见原因：TETFund National Research Fund 2019（拨款编号：TETFund/DR&D/CE/NRF/STI/33）。
Pregnant women's hepatitis B vaccination coverage in Nigeria: a national pilot cross-sectional study.
Objective: To determine the hepatitis B vaccination coverage, full-dose (⩾3) coverage and the associated factors affecting uptake among pregnant women.
Methods: This was a cross-sectional study among pregnant women attending antenatal care in six tertiary hospitals across all the geopolitical zones of Nigeria. Pregnant women who consented to the study completed screening questions about their hepatitis B vaccination status and coverage. The main outcome measures were hepatitis B vaccination coverage rate, dose, and factors affecting uptake. Bivariate analysis was performed by the chi-square test and conditional logistic regression analysis was used to determine variables associated with uptake of the vaccination. Odds ratios (ORs) and adjusted odds ratios (aORs) were calculated and statistical significance was accepted when p-value was < 0.05.
Results: Of 159 pregnant women who completed the interview questions, 21 [13.2%, 95% confidence interval (CI) 7.9-18.5%] were vaccinated for hepatitis B for one to three doses. The numbers of doses received were: three doses (8/159, 5.0%), two doses (5/159, 3.1%), and one dose (8/159, 5.0%). The reasons for non-uptake of vaccination included: lack of awareness of the vaccine 83/138 (60.1%), inadequate access to vaccine 11/138 (8.0%), and positivity to hepatitis B virus 10/138 (7.2%). The uptake of hepatitis B vaccination was significantly affected by the level of education (OR 0.284, 95% CI 0.08-1.01, p = 0.041), but in multivariable logistic regression, adjusted for confounders, the association between hepatitis B vaccination and participants' level of education (aOR 3.09; 95% CI 0.95-10.16; p = 0.061) did not remain significant.
Conclusions: In Nigeria, the national hepatitis B vaccination coverage among pregnant women appears poor, with the full-dose coverage even poorer. The level of education was not positively associated with uptake of hepatitis B vaccination, while lack of awareness of the vaccine was the commonest reason for non-uptake.
Funding: TETFund National Research Fund 2019 (grant number TETFund/DR&D/CE/NRF/STI/33).
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