[18F]PI-2620半定量评价认知正常、轻度认知障碍及阿尔茨海默病患者Tau沉积

IF 2.2 4区 医学 Q3 BIOCHEMICAL RESEARCH METHODS
Molecular Imaging Pub Date : 2021-07-09 eCollection Date: 2021-01-01 DOI:10.1155/2021/6640054
Attapon Jantarato, Sira Vachatimanont, Natphimol Boonkawin, Sukanya Yaset, Anchisa Kunawudhi, Chetsadaporn Promteangtrong, Jintana Assanasen, Nithi Mahanonda, Chanisa Chotipanich
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引用次数: 5

摘要

背景:一些研究报道了[18F]PI-2620作为有效的tau结合放射性示踪剂的有效性;然而,很少有报道将半定量分析应用于示踪剂。因此,本研究的目的是对正常认知个体和轻度认知障碍(MCI)和阿尔茨海默病(AD)患者[18F]PI-2620进行半定量分析。方法:选取认知正常(CN)受试者26例,AD患者7例,MCI患者36例。注射后30-75分钟进行动态正电子发射断层扫描(PET)。PET和t1加权磁共振成像扫描共登记。采用标准化吸收值比(SUVr)进行半定量分析。P-Mod软件被应用于创建感兴趣的体积。采用方差分析和事后Tukey HSD进行统计分析。结果:AD组枕叶平均SUVr(1.46±0.57)明显高于CN组和MCI组。与CN组相比,AD组梭状回(1.06±0.09比1.49±0.86)、下颞叶(1.07±0.07比1.46±0.08)、顶叶、舌回和楔前叶区的平均SUVr显著高于CN组。同样,AD组在楔前叶、舌区、颞下区、梭状回区、边缘上区、眶额区和颞上区表现出比MCI组更高的平均SUVr。其余观察到的区域,包括纹状体、基底神经节、丘脑和白质,在所有组中都显示出较低的SUVr,没有统计学上的显著差异。结论:AD组[18F]PI-2620的平均SUVr显著升高;AD组的大脑显著区域显示tau蛋白沉积与Braak III-V期一致,为区分AD与CN和MCI提供了有用的信息。此外,深纹状体和丘脑的低SUVr可能有助于排除原发性病变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

The Evaluation of Tau Deposition with [<sup>18</sup>F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer's Disease.

The Evaluation of Tau Deposition with [<sup>18</sup>F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer's Disease.

The Evaluation of Tau Deposition with [<sup>18</sup>F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer's Disease.

The Evaluation of Tau Deposition with [18F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer's Disease.

Background: Some studies have reported the effectiveness of [18F]PI-2620 as an effective tau-binding radiotracer; however, few reports have applied semiquantitative analysis to the tracer. Therefore, this study's aim was to perform a semiquantitative analysis of [18F]PI-2620 in individuals with normal cognition and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods: Twenty-six cognitively normal (CN) subjects, 7 patients with AD, and 36 patients with MCI were enrolled. A dynamic positron emission tomography (PET) scan was performed 30-75 min postinjection. PET and T1-weighted magnetic resonance imaging scans were coregistered. The standardized uptake value ratio (SUVr) was used for semiquantitative analysis. The P-Mod software was applied to create volumes of interest. The ANOVA and post hoc Tukey HSD were used for statistical analysis.

Results: In the AD group, the occipital lobe had a significantly higher mean SUVr (1.46 ± 0.57) than in the CN and MCI groups. Compared with the CN group, the AD group showed significantly higher mean SUVr in the fusiform gyrus (1.06 ± 0.09 vs. 1.49 ± 0.86), inferior temporal (1.07 ± 0.07 vs. 1.46 ± 0.08), parietal lobe, lingual gyrus, and precuneus regions. Similarly, the AD group demonstrated a higher mean SUVr than the MCI group in the precuneus, lingual, inferior temporal, fusiform, supramarginal, orbitofrontal, and superior temporal regions. The remaining observed regions, including the striatum, basal ganglia, thalamus, and white matter, showed a low SUVr across all groups with no statistically significant differences.

Conclusion: A significantly higher mean SUVr of [18F]PI-2620 was observed in the AD group; a significant area of the brain in the AD group demonstrated tau protein deposit in concordance with Braak Stages III-V, providing useful information to differentiate AD from CN and MCI. Moreover, the low SUVr in the deep striatum and thalamus could be useful for excluding primary tauopathies.

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来源期刊
Molecular Imaging
Molecular Imaging Biochemistry, Genetics and Molecular Biology-Biotechnology
自引率
3.60%
发文量
21
期刊介绍: Molecular Imaging is a peer-reviewed, open access journal highlighting the breadth of molecular imaging research from basic science to preclinical studies to human applications. This serves both the scientific and clinical communities by disseminating novel results and concepts relevant to the biological study of normal and disease processes in both basic and translational studies ranging from mice to humans.
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