预测晚期胃癌新辅助化疗和根治性手术后生存的Nomogram。

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2021-07-28 eCollection Date: 2021-01-01 DOI:10.1155/2021/2923700
Yonghe Chen, Dan Liu, Jian Xiao, Jun Xiang, Aihong Liu, Shi Chen, Junjie Liu, Xiansheng Hu, Junsheng Peng
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引用次数: 3

摘要

背景:新辅助化疗(NAC)加根治性手术已成为世界范围内晚期胃癌(AGC)的一种流行治疗方式。然而,生存效益仍有争议,预后因素仍不确定。目的:确定与AGC患者NAC及根治性手术后生存相关的临床参数,建立多因素综合nomogram预测生存。方法:我们回顾了215例接受NAC和根治性切除术的AGC患者的医学资料,并使用Cox回归模型分析了NAC、手术、病理表现和辅助化疗的临床参数,以确定它们对生存的影响。基于这些因素,开发并验证了nomogram。结果:1年和3年生存率分别为85.8%和55.6%。结论:建立了预测NAC和手术后生存的nomogram。由于该nomogram具有令人满意且稳定的预测能力,因此可以推断该nomogram是预测AGC患者NAC及根治性手术后生存的实用工具。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery.

Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery.

Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery.

Nomogram for Predicting Survival in Advanced Gastric Cancer after Neoadjuvant Chemotherapy and Radical Surgery.

Background: Neoadjuvant chemotherapy (NAC) with subsequent radical surgery has become a popular treatment modality for advanced gastric cancer (AGC) worldwide. However, the survival benefit is still controversial, and prognostic factors remain undetermined.

Aim: To identify clinical parameters that are associated with the survival of AGC patients after NAC and radical surgery and to establish a nomogram integrating multiple factors to predict survival.

Methods: We reviewed the medical profiles of 215 AGC patients who received NAC and radical resection, and clinical parameters concerning NAC, surgery, pathological findings, and adjuvant chemotherapy were analyzed using a Cox regression model to determine their impact on survival. Based on these factors, a nomogram was developed and validated.

Results: The overall 1-year and 3-year survival rates were 85.8% and 55.6%, respectively. Younger age (<60 years old), increased examined lymph nodes (exLNs), successful R0 resection, the achievement of pathological complete response (pCR), and acceptance of adjuvant chemotherapy were positive predictors of survival. The C-index of the established nomogram was 0.785. The area under receiver operating curve (ROC) at 1/3 years of prediction was 0.694/0.736, respectively. The model showed an ideal calibration following internal bootstrap validation.

Conclusion: A nomogram predicting survival after NAC and surgery was established. Since this nomogram exhibited satisfactory and stable predictive power, it can be inferred that this is a practical tool for predicting AGC patient survival after NAC and radical surgery.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
期刊介绍: ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.
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