与健康对照相比,超活动型埃勒-丹洛斯综合征患者的颅面形态和上呼吸道尺寸。

IF 1 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
eJournal of Oral Maxillofacial Research Pub Date : 2021-06-30 eCollection Date: 2021-04-01 DOI:10.5037/jomr.2021.12205
Liselotte Sonnesen, Tessie Pawlik, Eva Fejerskov Lauridsen
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引用次数: 1

摘要

目的:本病例对照研究的目的是比较多动型埃勒-丹洛斯综合征患者与健康对照者的颅面形态、气道最小横截面积和气道体积。材料和方法:样本包括18例经临床诊断并进行基因检测以排除其他类型EDS的hEDS患者(16例女性,2例男性,平均年龄34.1 [SD 10.35]岁),以及16例中性闭塞、颅面形态正常的对照组(14例女性,2例男性,平均年龄37.9 [SD 10.87]岁)。颅面形态通过侧位脑电图进行评估。最小横截面积和上气道容积通过锥形束计算机断层扫描进行评估,并通过标准和有效的方法进行分析。通过调整年龄、性别和身体质量指数(BMI)的logistic回归分析来检验差异。结果:hEDS患者的颅面形态与对照组无明显差异。hEDS患者的气道最小横截面积(P = 0.019)和气道体积(P = 0.044)均明显小于对照组。当对年龄、性别和BMI进行调整时,没有发现显著差异。然而,最小横截面积几乎显著(P = 0.077)。结论:超活动性ehers - danlos综合征患者颅面形态和气道尺寸与对照组相当,且超活动性ehers - danlos综合征组的最小横截面积倾向于更小。该结果可能对了解超活动型ehers - danlos综合征对颅面形态和上呼吸道的影响有价值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls.

Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls.

Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls.

Craniofacial Morphology and Upper Airway Dimensions in Patients with Hypermobile Ehlers-Danlos Syndrome Compared to Healthy Controls.

Objectives: The aims of the present case-control study were to compare craniofacial morphology, airway minimum cross-sectional area and airway volume between patients with hypermobile Ehlers-Danlos syndrome and healthy controls.

Material and methods: The sample comprised 18 hypermobile Ehlers-Danlos syndrome (hEDS) patients (16 females, 2 males, mean age 34.1 [SD 10.35] years), clinically diagnosed and genetically tested in order to exclude other types of EDS, and 16 controls (14 females, 2 males, mean age 37.9 [SD 10.87] years) with neutral occlusion and normal craniofacial morphology. Craniofacial morphology was assessed on lateral cephalograms. Minimum cross-sectional area and upper airway volume were assessed on cone-beam computed tomography and analysed by standard and well-validated methods. Differences were tested by logistic regression analysis adjusted for age, gender and body mass index (BMI).

Results: No significant differences in craniofacial morphology were found between hEDS patients and controls. Airway minimum cross-sectional area (P = 0.019) and airway volume (P = 0.044) were significantly smaller in hEDS patients compared to controls. When adjusted for age, gender and BMI no significant differences were found. However, minimum cross-sectional area was almost significant (P = 0.077).

Conclusions: The craniofacial morphology and airway dimensions of hypermobile Ehlers-Danlos syndrome patients were comparable to controls, with a tendency towards a smaller minimum cross-sectional area in the hypermobile Ehlers-Danlos syndrome group. The results may prove valuable for understanding the effect of hypermobile Ehlers-Danlos syndrome on craniofacial morphology and the upper airways.

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