一项基于人群的慢性肾病亚临床甲状腺功能减退患病率研究:德黑兰甲状腺研究

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM
International Journal of Endocrinology and Metabolism Pub Date : 2021-03-17 eCollection Date: 2021-04-01 DOI:10.5812/ijem.103750
Sara Kazempour-Ardebili, Atefeh Amouzegar, Maryam Tohidi, Atieh Amouzegar, Fereidoun Azizi
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引用次数: 1

摘要

背景:慢性肾脏疾病(CKD)是一个日益严重的公共卫生问题,对心血管健康和总体生存有不利影响。在一般人群中,亚临床甲状腺功能减退症(SCH)与不良预后相关。它被认为在CKD患者中更为普遍,它们的共存可能导致这些患者预后不良。我们的目的是确定慢性肾病中SCH的患病率。方法:使用来自德黑兰甲状腺研究的数据,这是一项前瞻性人群队列研究,选择肾小球滤过率(eGFR)估计为60 mL/min/1.73 m2或以下的成人受试者,研究甲状腺异常的患病率,以及其他已知的心血管危险因素。结果:在招募的5626名受试者中,823人(14.6%)患有CKD。CKD患者年龄较大,体重较重,糖尿病患病率较高,血清促甲状腺素和甲状腺过氧化物酶抗体水平较高,但游离甲状腺素水平较低。肾脏疾病和非肾脏疾病患者的SCH患病率分别为7.3%和5.2% (P < 0.001)。然而,在调整年龄、性别、BMI、吸烟和TPOAb后,CKD和非CKD受试者之间发生SCH的风险没有差异(OR: 1.28;95%ci, 0.89 - 1.83)。在调整年龄和性别后,有和没有SCH的CKD亚组之间的代谢标志物比较没有统计学意义上的显著差异。结论:在控制了混杂因素后,慢性阻塞性肺病的SCH患病率并不高。此外,有无SCH的CKD受试者的代谢参数没有差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Prevalence of Subclinical Hypothyroidism in Chronic Kidney Disease in a Population-based Study: Tehran Thyroid Study.

Background: Chronic kidney disease (CKD) is a rising public health concern that has detrimental effects on cardiovascular health and overall survival. Subclinical hypothyroidism (SCH) has been associated with poor outcomes in the general population. It is thought to be more prevalent in CKD subjects, and their coexistence may contribute to poor outcomes in these patients. We aimed to determine the prevalence of SCH in CKD.

Methods: Using data from the Tehran thyroid study, which is a prospective population-based cohort study, adult subjects with an estimated Glomerular Filtration Rate (eGFR) of 60 mL/min/1.73 m2 or less were selected for studying the prevalence of thyroid abnormalities, as well as other known cardiovascular risk factors.

Results: Of 5,626 subjects recruited, 823 (14.6%) individuals had CKD. Individuals with CKD were older, heavier, had a higher prevalence of diabetes, higher serum thyrotropin, and thyroid peroxidase anti-body levels, but lower free thyroxine levels. The prevalence of SCH was 7.3% and 5.2% (P < 0.001) in kidney disease and non-kidney disease subjects, respectively. However, there was no difference in the risk of SCH between CKD and non-CKD subjects after adjustment for age, sex, BMI, smoking, and TPOAb (OR: 1.28; 95%CI, 0.89 - 1.83). None of the metabolic markers compared between the CKD subgroups of those with and without SCH remained statistically significantly different after adjusting for age and gender.

Conclusions: The prevalence of SCH was not higher in CKD after controlling for confounding factors. Besides, CKD subjects with and without SCH had no different metabolic parameters.

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来源期刊
CiteScore
3.10
自引率
4.80%
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0
期刊介绍: The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.
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