T2wsup-dMRI弥散成像技术。

IF 2.5 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Magnetic Resonance in Medical Sciences Pub Date : 2022-07-01 Epub Date: 2021-08-03 DOI:10.2463/mrms.mp.2021-0007
Tokunori Kimura, Kousuke Yamashita, Kouta Fukatsu
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引用次数: 0

摘要

目的:本研究提出并评估了一种新的弥散性MRI (dMRI)技术,结合基于t2的水抑制(T2wsup)技术,解决了脑脊液(CSF)部分体积效应(PVEs)对脑组织造成的参数图(表观扩散系数[ADC]或平均扩散系数[MD],分数各向异性[FA])量化和纤维束造影(FT)错误绘制的问题。方法:利用长TE水信号优势图像对多回波时间(TE)图像的信号强度进行校正后,从获取的多b值(b) DWI图像中减去t2wsupp -弥散加权成像(DWI)图像。从最小数据点获得定量参数图和FT,并与使用标准(无wsup) DWI方法的结果进行比较,并与使用其他替代DWI方法(应用流体衰减反演恢复(FLAIR),非b-零(NBZ))通过理论或添加噪声的模拟和MR图像获得的结果进行部分比较。结果:T2wsup-dMRI方法在保持组织信噪比的同时,即使在较低的b下(≤500 s/mm2),也能显著抑制MRI数据中csf - pve引起的高信号伪影。即使在健康脑组织的水(CSF) PVE体素中(T2 > 100 ms),定量参数图值也精确接近纯组织值。此外,纤维束连接正确,特别是在与脑脊液最接近的穹窿处。结论:我们提出的T2wsup-dMRI技术易于解决目前dMRI技术中CSF-PVE的问题,在应用于健康脑组织时,其信噪比高于FLAIR或NBZ方法。尽管需要进一步优化脉冲序列、处理技术和临床评估,特别是对于长T2病变,建议的T2wsup-dMRI可能在临床环境中有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Diffusion MR Imaging with T2-based Water Suppression (T2wsup-dMRI).

Diffusion MR Imaging with T2-based Water Suppression (T2wsup-dMRI).

Diffusion MR Imaging with T2-based Water Suppression (T2wsup-dMRI).

Diffusion MR Imaging with T2-based Water Suppression (T2wsup-dMRI).

Purpose: This study proposes and assesses a new diffusion MRI (dMRI) technique to solve problems related to the quantification of parameter maps (apparent diffusion coefficient [ADC] or mean diffusivity [MD], fractional anisotropy [FA]) and misdrawing of fiber tractography (FT) due to cerebrospinal fluid (CSF)-partial volume effects (PVEs) for brain tissues by combining with the T2-based water suppression (T2wsup) technique.

Methods: T2wsup-diffusion-weighted imaging (DWI) images were obtained by subtracting those images from the acquired multi-b value (b) DWI images after correcting the signal intensities of multiecho time (TE) images using long TE water signal-dominant images. Quantitative parameter maps and FT were obtained from minimum data points and were compared with those using the standard (without wsup) DWI method, and partly compared with those obtained using other alternative DWI methods of applying fluid attenuation inversion recovery (FLAIR), non-b-zero (NBZ) by theoretical or noise-added simulation and MR images.

Results: In the T2wsup-dMRI method, the hyperintense artifacts due to CSF-PVEs in MRI data were dramatically suppressed even at lower b (≲ 500 s/mm2) while keeping the tissue SNR. The quantitative parameter map values became precisely close to the pure tissue values precisely even in water (CSF) PVE voxels in healthy brain tissues (T2 ≲ 100 ms). Furthermore, the fiber tracts were correctly connected, particularly at the fornix in closest contact to the CSF.

Conclusion: Solving the problem of CSF-PVE in the current dMRI technique using our proposed T2wsup-dMRI technique is easy, with higher SNR than those obtained with FLAIR or NBZ methods when applying to healthy brain tissues. The proposed T2wsup-dMRI could be useful in clinical settings, although further optimization of the pulse sequence and processing techniques and clinical assessments are required, particularly for long T2 lesions.

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来源期刊
Magnetic Resonance in Medical Sciences
Magnetic Resonance in Medical Sciences RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
5.80
自引率
20.00%
发文量
71
审稿时长
>12 weeks
期刊介绍: Magnetic Resonance in Medical Sciences (MRMS or Magn Reson Med Sci) is an international journal pursuing the publication of original articles contributing to the progress of magnetic resonance in the field of biomedical sciences including technical developments and clinical applications. MRMS is an official journal of the Japanese Society for Magnetic Resonance in Medicine (JSMRM).
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